E-4 CBC Parameters and Associated Indications
E.3 Platelet Parameters and Associated Indications
Table E-3: Platelet Parameters and Associated Indications
Parameter Increase in Disease State Decrease in Disease State
Total Platelet Count Thrombocytosis is present with excess
bleeding, iron deficiency anemia and
myeloproliferative syndromes.
• Disseminated intravascular coagulation
• Bone marrow depression
• Autoimmune hemolytic anemia
• Severe hemorrhage
• Liver disease
• Parasites
MPV
Mean Platelet Volume
Indirect evidence of increased (bone mar-
row) megakaryocyte response.
Not an accurate predictor of decreased mega-
karyocyte response.
PCT
Platelet Hematocrit
Volume of platelets expressed as a per-
centage of whole blood (used as a
research tool).
Volume of platelets expressed as a percent-
age of whole blood (used as a research tool).
PDW
Platelet Distribution
Width
Increased measure of platelet anisocyto-
sis (platelet size variation) indicative of
active platelet release.
No known clinical significance.