Inner Workings – Triple Quadrupole MS versus Single Quadrupole MS 2
Triple quadrupole MS operation
Agilent 6400 Series Triple Quad LC/MS Concepts Guide 21
Triple quadrupole MS operation
Be sure to read the previous section on the concepts behind the
operation of a single quadrupole mass spectrometer.
Understanding these concepts helps you understand the
operation of the triple quadrupole mass spectrometer.
Design of the Agilent Triple Quadrupole MS
The triple quadrupole mass spectrometer consists of an ion
source, enhanced desolvation technology, followed by ion optics
that transfer the ions to the first quadrupole positioned to the
right of it. A diagram of some of the current Triple Quadrupole
LC/MS products is shown in Figure 7 on page 22. The Agilent
6430 is shown in Figure 8 on page 23.
Agilent 6400 Series Triple
Quadrupole System
Highlights
6420 • Includes one turbo pump and one rough pump
• Includes resistive capillary
• Can upgrade to a 6430
6430 • Adds an additional turbo pump
• Improves pumping in vacuum stage 2
• Updates collision cell lenses
• Can upgrade to a 6460
6460 • Includes Agilent Jet Stream Technology
• Includes 3,000 m/z Q1 and Q2 quadrupoles
6490 • Includes iFunnel technology (Agilent Jet
Stream, hexabore capillary, and high
pressure/low pressure ion funnels)
• Adds additional rough pump for ion funnel
• Includes high throughput quadrupole driver
electronics
• Includes curved collision cell assembly
• Has a smaller footprint
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