Inner Workings – Triple Quadrupole MS versus Single Quadrupole MS 2
Innovative Enhancements in the 6460 Triple Quadrupole
Agilent 6400 Series Triple Quad LC/MS Concepts Guide 25
The Dual Ion Funnel (DIF) technology is the second
enhancement. The DIF technology removes the gas and neutral
noise but captures the ions. It also extends the turbo pump’s
lifetime. The Dual Ion Funnel technology can transmit ions
efficiently at as high a pressure as possible. The first ion funnel
has a pressure between 7 and 14 torr. The second ion funnel is a
low pressure ion funnel (1 to 3 torr). The ion funnel works by
having the RF voltage focus the ions to the center and having
the DC voltage accelerate the ions to the exit. See Figure 11.
The hexapole field axial focusing curved collision cell is the
third enhancement. It includes a tapered cell structure for
increased ion acceptance at the entrance. Its structure reduces
the ionizer generated noise.
The fourth enhancement is the improved quadrupole drive
electronics. The higher drive frequency produces more ion
motion cycles in the quadrupole mass filter. More ion motion
cycles gives higher mass resolution. You can tune a 6490 to 0.4
m/z. The higher drive frequency does reduce the mass range to
1400 m/z.
Innovative Enhancements in the 6460 Triple Quadrupole
Ions are generated using an electrospray ion source where the
analyte is simultaneously ionized and desolvated from the
liquid matrix. The first of five (5) innovative Agilent
enhancements is found in the application of Agilent Jet Stream
Technology (denoted as 1 on the 6460 in Figure 7 on page 22)
which improves sensitivity via thermal gradient focusing and
enhanced desolvation.
Figure 11 The Dual Ion Funnel technology
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