54 Agilent 6400 Series Triple Quad LC/MS Concepts Guide
3 Agilent Triple Quadrupole MS and Sensitivity
LC/MS ion sources
HPLC-Chip
Traditional nanospray mass spectrometry has proven its
potential as a cost-effective, sensitive and reproducible
technique for the identification of peptides at femtomol to
atomol levels. However, connecting nano capillaries, columns
and valves frequently is a tedious procedure and requires user
skills and routine. When handled incorrectly, nano flow
connections are prone to leakage which are difficult to detect
and result in poor system performance and extended downtime
of the complete system. Quartz nanospray needles are prone to
blockages and require frequent replacement.
With the invention of HPLC-Chip technology, Agilent is
significantly reducing the need for user interaction and making
nanospray a rugged state-of-the-art technology. See the
documentation for the HPLC-Chip for more information.
Commercially available Agilent chip solutions:
Application
Chip
Peptide/Protein ID ProtID-Chip
Intact Protein Analysis Protein Chip
Glycan Analysis PGC-Chip
Phosphopeptide Analysis Phosphochip
Small Molecule Analysis SmlMol-Chip
Monoclonal Antibody Glycan Analysis mAb-Glyco Chip
Custom User Desired Analysis Custom Chip
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