Discover Bio
Manual Peptide Synthesizer
Installation and Operation Instructions
Contents
600423
Rev. 2
August 2017
Introduction to the Discover Bio 2
System Requirements 3
Hardware Assembly and Setup 4
Wash Station Setup 4
Discover Setup 7
General Instrument Operation 8
Programming a New Method 8
Loading an Existing Method 8
Recommended Synthesis Parameters 9
Recommended Microwave Methods 9
Recommended Reagents for 0.1 mmol Scale 9
General Discover Bio Methods 11
Swelling the Resin 11
Performing a Deprotection 12
Performing a Coupling 12
Performing a Cleavage 13
Using the 4 mL Vessel for Smaller Scale 15
Connecting the 4 mL Vessel 15
Maintenance Procedures 16
After Each Use 16
Monthly Maintenance 16
Semiannual Maintenance 16
Replacement of RV Frit 16
Spare Parts and Accessories 18
System 18
Accessories and Consumables 18
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