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Millipore Labscale User Manual

Millipore Labscale
60 pages
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Labscale
Tangential
Flow Filtration System
User Guide

Questions and Answers:

Millipore Labscale Specifications

General IconGeneral
ApplicationTangential Flow Filtration (TFF)
Membrane Area0.1 to 0.1 m²
Materials of ConstructionPolypropylene, stainless steel
Pump TypePeristaltic
Pressure MonitoringYes, pressure gauges or transducers
SterilizationAutoclavable
Membrane MaterialPolyethersulfone (PES), regenerated cellulose
Temperature Range4°C to 40°C
Housing MaterialPolypropylene

Summary

Introduction and Safety

Operator and Equipment Safety

Essential safety precautions for operating the Labscale system and handling equipment.

System Setup and Components

Labscale Stirbase Setup

Instructions for setting up the Labscale Stirbase and module.

Operating Requirements

Details on power supply, operating, and storage conditions for the system.

System Overview and Unpacking Lists

Overview of the Labscale TFF system and its packaging.

Labscale 500 mL Reservoir

Details and diagram of the Labscale 500 mL Reservoir, including gauges.

Labscale Stir Base

Description of the Labscale Stir Base, including its stirrer and accessories.

Labscale Pump Module

Description of the Labscale Pump Module, its components, and accessories.

Pellicon XL 50 Device and User Supplied Materials

Information on the Pellicon XL device and user-supplied materials.

Labscale TFF System Setup

General guide for setting up the Labscale TFF system.

Labscale 500 mL Reservoir Setup

Detailed instructions for setting up the Labscale 500 mL Reservoir.

Labscale Stir Base Set Up

Instructions for connecting and setting up the Labscale Stir Base.

Labscale Pump Module Set Up

Procedures for installing the Labscale Pump Module into the Stir Base.

System Operation Procedures

Install Cleaning Tubing

Steps for installing the cleaning tubing for the system.

Clean System

Step-by-step guide for cleaning the Labscale TFF system.

Drain System

Instructions on how to properly drain the system.

Flush System

Steps for flushing the Labscale TFF system.

Flushing Device and Pellicon XL Installation

Instructions for setting up the flushing device and installing the Pellicon XL.

Flushing the Pellicon XL Device

Detailed steps for flushing the Pellicon XL device.

Integrity Testing—Pellicon XL Device

Procedures for performing integrity tests on the Pellicon XL device.

Preconditioning

Steps for preconditioning the Labscale TFF system before use.

Concentration

Guide on how to perform concentration using the system.

Product Recovery

Steps for recovering the product from the system.

Diafiltration-Vacuum

Instructions for performing diafiltration using a vacuum.

Shutdown and Maintenance

System Shutdown

Procedures for shutting down the system.

Cleaning Device

Information on cleaning the device.

Recommended Cleaning Solutions

Table of recommended cleaning agents and conditions.

Clean System

Detailed steps for cleaning the system.

Drain System Post-Shutdown

Steps for draining the system after cleaning.

Flushing Device Post-Shutdown

Instructions for flushing the device after cleaning.

Clean Base

Method for cleaning the exterior of the system base and reservoir.

Specifications, Ordering, and Troubleshooting

Specifications

Detailed technical specifications including dimensions, weight, pressure, and power.

Materials of Construction

List of materials used for various components of the system.

EC Compliance Certificate

Information regarding the EC compliance and applicable standards.

Labscale TFF System Ordering Information

Ordering information for the TFF system, components, and compatible parts.

System Maintenance and Spare Parts

Lists of spare parts for system maintenance.

Pump Check Valve Flushing

Steps for flushing the pump check valves.

Diaphragm Pump Maintenance

Detailed procedures for diaphragm pump maintenance and part replacement.

System Troubleshooting

Troubleshooting for electrical, performance, and pressure issues.

Technical Assistance

Information on how to contact Millipore for technical assistance.

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