Chapter 4 Analog Input
NI USB-621x User Manual 4-38 ni.com
Figure 4-25.  Connecting to the USB-6215/6216/6218 in Referenced 
Single-Ended Mode
In an referenced single-ended connection configuration, each input channel 
is measured with respect to AI GND.
Taking Non-Referenced Single-Ended Measurements
To reach a compromise between referenced single-ended and differential 
measurements, you can use an non-referenced single-ended measurement 
configuration. This configuration allows for a remote sense for the negative 
(–) input of the instrumentation amplifier (PGIA) that is shared among all 
channels configured for non-referenced single-ended mode. The behavior 
of this configuration is similar to that of referenced single-ended 
connections, except it provides improved noise rejection. Figure 4-26 
shows an non-referenced single-ended connection configuration.
Figure 4-26.  Connecting to the USB-6215/6216/6218 in Non-Referenced 
Single-Ended Mode
In non-referenced single-ended connection configuration, each input 
channel is measured with respect to AI SENSE.
AI 1
AI 2
AI GND
USB-6215/6216/6218
Mux
ADCPGIA
AI 1
AI 0
AI GND
Mux
ADC
PGIA
AI SENSE
USB-6215/6216/6218