Pall T Series User Manual

Name: Pall T Series
Brand: Pall
Rating: 5 (1 reviews)

51 pages

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User Guide

T-Series TFF Cassettes

with Omega™ Membrane

Care and Use Procedures

For use with Centramate™ and Centrasette™ TFF Systems

USTR 2433b

Table of Contents2
Safety Notice4
Learn Bout Safety5
Important - Read First5
Safety Conventions in this Manual6
Introduction6
Pplications in TFF6
Tangential Flow Filtration Process6
The TFF Process7
System Hardware Configurations8
Options8
System Design9
Ports and Flow Rate9
T-Series Cassettes with Omega Membrane Installation9
First-Time Use of Cassette Holder/Tff System9
Flush and Clean the System9
Making a Flushing Gasket10
System Flushing Protocol10
Installing T-Series Membrane Cassettes with Omega Membrane into Utotorque ( T) and Manual Torque (MT) Holders11
Preparation for Loading Cassettes11
Unpacking the Cassettes11
Installing Cassettes and Gaskets13
How to Torque Pall T and MT Cassette Holders14
Operating Specifications17
Recommended Cross Flow Rates for T-Series Cassettes with Omega Membrane17
Operating Pressures, Temperatures and Ph18
Hold-Up Volume and Minimum Working Volume18
Determining Feed/Retentate Hold-Up Volume18
Determining Permeate Hold-Up Volume19
Determining the Non-Recoverable Volume20
Determining the System Minimum Working Volume20
Preconditioning T-Series Cassettes and Systems21
Using a Cassette for the First Time22
Initial Flushing of the Cassette and Ssembly (WFI Flush)22
Flush the Feed/Retentate and Permeate Line to Waste22
Sanitizing and Depyrogenating the Cassette and Ssembly23
DD and Recirculate Sanitizing Solution24
Flushing the Cassette and Ssembly after Sanitization24
Flush the Retentate and Permeate Line to Waste25
Water Recirculation25
Flush the Retentate and Permeate Line to Drain26
Determine Normalized Water Permeability (NWP20 °C) for Cassettes27
Remove Ir from Cassette and System28
Determine Initial Water Permeability (Dead-End Method)28
Normalize the Water Permeability30
Example of How to Determine Membrane Water Permeability30
System and Membrane Cassette Integrity Test31
Drain the System (Feed/Retentate Flow Path)32
System Integrity Test (External Test)33
Membrane Cassette Integrity Test33
Troubleshooting System Integrity Failure34
Troubleshooting Membrane Integrity Failure34
Integrity Testing Systems with Multiple Cassettes34
Buffer Conditioning35
Flush the Retentate and Permeate Lines with Buffer35
Remove Trapped Ir from the Retentate Line36
Post-Use Treatment of Cassettes and System37
Flushing Cassettes after Use37
Flush the Feed/Retentate Line to Waste37
Flush the Permeate Line to Waste38
Cleaning Cassettes38
Dding Cleaning Gent to System38
Recirculate Cleaning Solution39
Flush Cleaning Gent from Cassettes and Ssembly39
Flush the Retentate Line to Waste40
Flush the Permeate Line to Waste40
Recirculation Procedure to Reduce Ph, TOC, and Extractables (Optional)40
Determine Membrane Recovery for the Cassettes41
Remove Ir from Cassette and System42
Determine the Water Permeability after Cleaning42
Normalize the Water Permeability44
Determine the Membrane Recovery44
Evaluate the Effectiveness of the Cleaning Regimen44
Post-Use Ir Integrity Test (Optional)44
Storage of Membrane Cassettes45
Recommended Storage Gents for Omega Membranes45
Dding Storage Gent to System45
Recirculate Storage Solution46
Cassette Storage46
Ppendix47
Omega Membrane Chemical Compatibility Chart47
Lternative Cleaning Gents48
Glossary49

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Pall T Series Specifications

General

Brand	Pall
Model	T Series
Category	Laboratory Equipment
Language	English

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