EasyManua.ls Logo

Pall T Series - User Manual

Pall T Series
51 pages
Print Icon
To Next Page IconTo Next Page
To Next Page IconTo Next Page
Loading...
User Guide
T-Series TFF Cassettes
with Omega™ Membrane
Care and Use Procedures
For use with Centramate™ and Centrasette™ TFF Systems
USTR 2433b

Table of Contents

Question and Answer IconNeed help?

Do you have a question about the Pall T Series and is the answer not in the manual?

Summary

Learn About Safety

Important - Read First

Emphasizes the importance of reading safety instructions before proceeding with any operations.

Pre-use Recommended Storage Conditions

Guidelines for storing cassettes before initial use to maintain performance and integrity.

Introduction

Applications in TFF

Describes the various applications of Tangential Flow Filtration (TFF) in biopharmaceutical processes.

Tangential Flow Filtration Process

Explains the key parameters and considerations in the TFF process for optimal results.

The TFF Process

Outlines the sequential steps involved in a typical Tangential Flow Filtration process.

System Hardware Configurations

Details the essential components and configurations for TFF systems.

T-Series Cassettes with Omega Membrane Installation

First-time Use of Cassette Holder;TFF System

Procedures for preparing a new cassette holder or TFF system for first-time operation.

Installing T-Series Membrane Cassettes with Omega Membrane into Autotorque (AT) and Manual Torque (MT) Holders

Step-by-step guide for installing T-Series cassettes into specific holder types.

How to Torque Pall AT and MT Cassette Holders

Instructions on correctly applying torque or hydraulic pressure to cassette holders.

Operating Specifications

Recommended Cross Flow Rates for T-Series Cassettes with Omega Membrane

Lists recommended cross flow flux rates for T-Series cassettes during operation.

Operating Pressures, Temperatures and pH

Details the operating limits for pressure, temperature, and pH for cassettes.

Hold-up Volume and Minimum Working Volume

Explains how to determine system hold-up and minimum working volumes.

Preconditioning T-Series Cassettes and Systems

Using a Cassette for the First Time

Procedures for the initial use of new Omega membrane cassettes to remove storage agents.

Sanitizing and Depyrogenating the Cassette and Assembly

Recommended agents and conditions for sanitizing and depyrogenating cassettes.

System and Membrane Cassette Integrity Test

Procedures for testing the integrity of the system and membrane cassettes.

Buffer Conditioning

Steps for preparing cassettes and the system with buffer solution for process readiness.

Post-use Treatment of Cassettes and System

Flushing Cassettes after Use

Procedures for flushing cassettes after the TFF process is completed.

Cleaning Cassettes

Recommended cleaning agents and solutions for cassettes to ensure reusability.

Determine Membrane Recovery for the Cassettes

Method to calculate membrane recovery efficiency after cleaning.

Storage of Membrane Cassettes

Guidelines and procedures for proper storage of membrane cassettes to maintain integrity.

Appendix

Omega Membrane Chemical Compatibility Chart

A chart detailing the compatibility of Omega membranes with various reagents.

Alternative Cleaning Agents

Lists alternative agents and their modes of cleaning for different foulants.

Glossary

Tangential Flow Filtration (TFF) (Cross Flow Filtration)

Defines the process using a pump to circulate sample across membranes.

Normalized Water Permeability (NWP)

Defines water flux measured at 20 °C divided by average TMP.

NWP Recovery

Defines the ratio of NWP after cleaning to initial NWP.

Pall T Series Specifications

General IconGeneral
BrandPall
ModelT Series
CategoryLaboratory Equipment
LanguageEnglish

Related product manuals