XCell® ATF 2 and 4 Stainless Steel Housings
SG-SSATF24 rev 1
7. XCell® ATF 4 Stainless Steel Housing
XCell® ATF 4 Stainless Steel Housing (Figure 7) is recommended for use with 10 – 50 L bioreactors.
The assembly of the housing and accessories includes installing the diaphragm and hollow fiber filter
into the housing, connecting the tubing set kit to the bioreactor, and connecting the harvest line to
the housing. The system is prepared for use by pressure testing, filter wetting, integrity testing, and
autoclaving.
Figure 7. XCell® ATF 4 Stainless Steel Housing
7.1 XCell® ATF 4 Stainless steel Housing assembly
XCell® ATF 4 Stainless Steel Housing assembly includes installation of the diaphragm and hollow fiber
filter and assembly of the tubing set kit that will connect the housing and the bioreactor and the
tubing that will connect the housing and the harvest vessel.
7.1.1 Installing the diaphragm
Important: The silicone diaphragm must be replaced after each run and prior to sterilization. To
avoid premature failure, it is important to ensure that the diaphragm is seated in the correct
orientation. Use with aqueous liquids only. For use with other fluids contact Repligen for a technical
discussion. When used as instructed, the diaphragm is designed to last over one million
pressure/exhaust cycles.
2. Permeate/Harvest
3. Retentate
4. Diaphragm pump
5. Air inlet
6. Drain Port
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