Agilent Technologies gc/ms series User Manual

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Inlets
Packed column analysis is frequently done when high efficiency separations are not
needed or when gases are analyzed by gas-solid chromatography. Purged packed inlets
are simple in both design and use. Few parameters need to be set, and all carrier gas
flow flushes through the inlet into the column in the standard configuration.
Purged Packed Inlet Practices and Rationales
Parameter Selection/Setting Rationale
Inlet temperature BP of solvent +50°C
BP of major solute(s)
Ensures flash vaporization
Use for neat samples
Insert type 1/8 in. stainless steel
1/4 in. stainless steel
530 µm
Use for stainless steel column
only
Inserts permit connection of
columns up to 1/4 in. OD
Liner Glass Use to lower activity
(replaceable)
Initial column temperature Temperature programming Sharpens peaks and reduces run
time
Column type 1/8 in. packed stainless
1/4 in. packed glass
530 µm
Will not break
Better for polar or labile
compounds
Carrier gas flow 10-40 mL/min
10-60 mL/min
Use with N
2
carrier gas
Use with He or H
2
carrier gas
Purged Packed Inlets

Agilent Technologies gc/ms series Specifications

General

Dynamic Range	10^6
Mass Range	1050 amu
Mass Resolution	Unit mass resolution
Scan Speed	Up to 12, 500 amu/sec
Ionization Mode	Electron Ionization (EI), Chemical Ionization (CI)
Temperature Range	Up to 350°C
Vacuum System	Turbomolecular Pump
Data System	Agilent MassHunter

Summary

Gas Management

Gas Purity and Selection

Gas Purification Systems

Overview of purifiers for removing oxygen, moisture, and hydrocarbons to achieve proper gas purity.

Sample Introduction

Selecting Vial Septa Materials

Gold Standard Autosampler Syringes

Syringe Troubleshooting Guide

Guidance on common syringe problems like bent plungers or needles and their solutions.

Inlets

Premium Non-Stick Septa

Split/Splitless Liners

Agilent MS Certified Liners

Split/Splitless Inlets

Overview of the popular split/splitless inlet and troubleshooting common issues like peak broadening.

Cool On-Column Inlets

Advantages of cool on-column injection, sample considerations, and troubleshooting tips.

Purged Packed Inlets

Programmed Temperature Vaporizer (PTV) Inlets

Benefits, practices, and rationales for PTV inlets, offering flexibility in sample introduction.

Detectors

Flame Ionization Detector (FID)

Routine maintenance, typical problems, and troubleshooting for the FID.

Electron Capture Detector (ECD)

Liner selection, makeup gas adapter maintenance, thermal cleaning, and leak testing for ECD.

Thermal Conductivity Detector (TCD)

Filament maintenance, lifetime extension, cell contamination, and solvent flush procedures for TCD.

Flame Photometric Detector (FPD)

Recommended gas flows, maintenance, contamination, and ignition problems for the FPD.

Nitrogen Phosphorus Detector (NPD)

GC/MS Systems

Maintaining Mass Selective Detectors (MSD)

Benefits of maintaining GC/MSD systems, including reduced downtime and longer lifespan.

MSD Contamination

Identifying contamination sources in the GC and MSD, and common contaminants and their origins.

Mass Spectrometer Symptoms

Ion Source

Installing a Capillary Column in the GC/MSD Interface

Vacuum Systems and Pumps