Christ Beta 1-8 LSCbasic - Page 10

Freeze-dryer Beta 1-8 LSCbasic
Freeze-dryer Beta 2-8 LSCbasic
1 General information
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Version 03/2018, Rev. 1.5 of 09/03/2020 • sb-dc
Translation of the original operating manual
The following table can be used as a general guide for the expected
degradation during normal freeze-drying processes of organic solvents with
a total max. concentration of 10 vol-% in aqueous solutions.
Solvent
Acrylic
glass
Stainless
steel
Silicon
rubber
EPDM
Acetic acid 20%
+
+
+
o
Formic acid
+
+
o
-
Trifluoracetic acid (TFA)
-
+
-
+
Calcium chloride
+
o
+
+
Sodium phosphate
+
+
-
+
Acetone
-
+
+
+
Acetonitrile
-
+
+
+
Carbon tetrachloride
-
+
-
-
Cyclohexane
+
+
-
-
Dioxane
+
+
-
o
Methyl-t-butyl ether
+
+
o
-
Pyridine
+
+
-
-
Methanol
-
+
+
+
Ethanol
o
+
+
+
tert-Butanol
-
+
o
o
DMSO
-
+
+
+
Legend:
+ No degradation to be expected
o Moderate degradation; limited use
- Severe degradation; infrequent use recommended;
immediate thorough cleaning required
The use of other solvents, e.g. ammonia, should be avoided.
The chemical attack on devices and accessory components can be
significantly reduced by immediate cleaning after the end of operation. All
parts of the freeze-dryer that have come in contact with the product must
be checked regularly for damages and replaced if necessary.
The following features are not permissible or must be deactivated:
• omission of product temperature sensors of the PT100 or LyoRx type or
of specially connected PT100 sensors (with a cable connection),
NOTE
Solvents that are not listed in the table above, or the listed solvents in a
concentration higher than 10% by volume, must not be used!