Edwards SAPIEN 3

20
The mean peak gradient decreased from 75.8 ± 22.6 mmHg at baseline to 21.2 ± 8.5 mmHg at 30 days,
as shown in Figure 7.
Figure 7:
Peak Gradient
(PIIS3HR VI Population)
The proportion of patients with AI ≥ moderate was 7.3% at baseline and 3.0% at 30 days, as shown in
Figure 8.
Figure 8:
Aortic Insufficiency
(PIIS3HR VI Population)
Peak Gradient (mmHg)
0
10
20
30
40
50
60
70
80
90
100
110
Baseline 30 Day
75.8
21.2
None Trace Mild
Mild-Moderate Moderate Moderate-Severe
Severe
Percentage
0
20
40
60
80
100
Baseline 30 Day
16%
30%
32%
32%
34%
27%
10%
8%
6%