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Introduction 7

Introduction

MESO SCALE DISCOVERY (MSD) develops, manufactures, and markets biological assays that provide cost-effective and valuable

information to scientists in drug discovery, therapeutic screening, and life science research. MSD's product portfolio is based on MULTI-

ARRAY

technology, a proprietary combination of patterned arrays and electrochemiluminescence detection that results in exceptional

sensitivity, speed, dynamic range, and convenience.

MSD

develops, manufactures, and markets detection instrument systems as well as a line of assay kits for use with these instruments, a

proprietary line of reagents, and custom microplate printing and assay development services. MSD

MULTI-ARRAY microplates are

available for the MESO QuickPlex

SQ 120 instrument in a 96-well format with standard or high-binding surfaces. MSD plates may be

purchased uncoated or coated with proteins such as streptavidin or avidin, with anti-species antibodies such as goat anti-mouse or goat

anti-rabbit, or with antibodies against specific analytes. Custom coatings and surface treatments are available.

MSD MULTI-ARRAY plates are available as single spot (single assay) plates and as MULTI-SPOT

plates with patterned spot arrays in

each well. MULTI-SPOT plates measure multiple analytes simultaneously in a single well, increasing throughput and enabling novel

assay panels.

For more details and information about applications, please visit the MSD website at www.mesoscale.com.

1.1 Intended Audience

This manual is for users of the MESO QuickPlex SQ 120 instrument. Users should have an understanding of general computer and

Microsoft

Windows terminology and be familiar with standard laboratory practices.

This manual describes how to operate the MESO QuickPlex SQ 120 instrument and acquire data using both SECTOR

and QUICKPLEX

plates. The analysis of this data is treated in a separate manual: DISCOVERY WORKBENCH

User’s Guide.

1.2 How to Use This Manual

This manual is organized by chapters containing main topics and subsections. Use the hyperlinked Table of Contents to find topics of

interest quickly. The List of Figures and List of Tables hyperlink to the images and tables that enhance understanding of written

information in the manual. The Appendix contains supplemental information on troubleshooting, instrument specifications, regulatory

information, and safety symbols and labels.

Tips

Symbol 

Tips provide extra information or details that help users perform functions more efficiently.

Notes

Notes provide supplemental information on the proper use of the QuickPlex SQ 120 instrument and its software.

MSD MESO QuickPlex SQ 120 User Manual

Questions and Answers: