IF.UG.IM_R1
3.2 Intended Use of the System
The KrosFlo® System is designed to execute traditional batch processes for concentration, with
several buffer exchange or wash steps.
The System will be fully configured for the disposable ProConnex® flow-paths, which include
flexible tubing, Hollow Fiber module or Cassette, disposable levitating pump head, pressure
transmitters, with associated connections or thermal plastic weldable tubing.
The System is assembled, wired, configured, and tested by Repligen prior to shipping and
installation at the client site.
Consumables such as Hollow Fiber Filter, Cassettes, Sensors, or Flow-paths are integrated parts
of the System, but they may require specific maintenance methods. Refer to the vendor-
provided User Guides for more information on these consumables.
3.3 Warnings for Moving, Installing, and Storing the System
1. The KrosFlo System is intended to be unpacked and installed by trained service personnel
only.
2. Do not attempt to lift the System. The System should only be moved by carefully rolling the
System on its casters. The System shipping crate includes an integral ramp that allows the
System to be rolled out of the crate.
3. Be sure to set the brake on each caster to prevent unintended motion.
4. The System is heavy and can cause crushing injury during a moving mishap. To prevent
injury, wear toe protection, such as steel-toe work boots.
5. Using a forklift (or other equipment moving machinery) of insufficient capacity can result in
unexpected dropping of the System, resulting in injury or death. To prevent injury or death
due to unexpected dropping, use a forklift rated to lift the weight of the System.
6. Careless moving of the heavy System can result in workers being squeezed or crushed
against other equipment or walls. To prevent squeezing and crushing injury, move the
equipment slowly and ensure workers do not position themselves where injury could result.
7. Do not allow the wheels of the System to run-off of ramps. Use a sufficient number of
movers to maintain control of the System, particularly when the System is on ramps.
WARNING – Only Authorized and Qualified Personnel are allowed to
use this equipment. Ensure installation, maintenance, and operation
are completed by qualified and trained personnel.
WARNING – If you use the System in a manner not specified in this user
guide, you may be exposed to hazards leading to personal injury or
equipment damage. Do not operate the System at temperatures or
pressures above those stated in this user guide.
WARNING – Always wear the personal protective equipment required
by the System owner’s safety program. This includes equipment to
prevent exposure to process fluids.
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