REPLIGEN KrosFlo SYITF-2000

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KrosFlo® Systems

User Guide

IF.UG.IM_R1

• Typical Feed Tank/Reservoir to KrosFlo System connection diagrams are presented as below:

If Hollow Fiber Filter is used:

If Cassette Filter is used:

Main Page

Table of Contents3
Introduction7
Safety Precautions7
Signal Words7
Table 1. Signal Words, Definitions, and Colors7
Safety Symbol Icons8
Table 2. Safety Symbol Icons8
Safety Guidelines9
Intended User Guide Audience9
Intended Use of the System10
Warnings for Moving, Installing, and Storing the System10
Warning for System Preparations11
Warnings for System Operation11
Warnings for System Maintenance14
System Specifications15
Table 3. Krosflo® System Feature/Component Specifications15
Table 4. Krosflo® System Electrical Specifications16
Table 5. Krosflo® System Environmental Specifications16
Figure 1. Sample Machine Designation Label16
System Dimensions17
Rohs and WEEE Compliance17
Figure 2. Krosflo® System Dimensions17
System Overview18
Main System18
Figure 3. Krosflo® System Overview18
Cassette Holder Cart (Optional)19
Auxiliary Cart (Optional)19
Figure 4. Optional Cassette Holder Cart19
Figure 5. Optional Auxiliary Cart19
Unpacking the System20
Performing Mechanical Installation21
Main System Assembly21
Figure 6. Pump Stand Assembly22
Cassette Holder Assembly (Optional)23
Cassettes Installation23
Figure 7. Cassette Installation23
Hydraulic Pump Preparation24
Figure 8. Hydraulic Pump Components24
Single-Use Flow-Path Assembly26
Recirculation Pump Preparation and Connections26
Figure 9. Typical Flow Path with Hollow Fiber and Cassette Filter Connections26
Feed Tank/Reservoir Connections30
Figure 10. Typical Feed Tank or Reservoir Connections30
Installing Auxiliary Pump Tubing32
Performing Electrical Installation33
Sensor and Communication Cables33
Pressure Sensors33
Installing Ferrite Bead for Pressure Sensors34
Installing Permeate Flow Sensors35
Other Sensor and Communication Cables35
Connecting the System Power Cables36
Using the System HMI36
Human Machine Interface (HMI) Overview36
Getting Started37
Loading and Running Recipes38
Figure 11. Recipe Selection Screen38
Home Screen39
Figure 12. Sample Home Screen39
Process Screen40
Figure 13. Sample Process Screen40
Alarms Screen42
Figure 14. Sample Alarms Screen42
Diagnostics Screen43
Figure 15. Sample Diagnostics Screen43
Operating the System44
Executing Reports44
System Emergency Stop and Responses45
Stopping the System Using the E-Stop Button45
Restarting the System after an Emergency Stop45
System Power Loss and Responses46
System Power Loss46
Restarting the System after a Power Loss46
Shutting down the System46
Performing System Maintenance47
Making the System Safe for Maintenance47
Cleaning the System47
Cleaning the Flow-Path47
Flow-Path Disassembly and Storage48
System Moving and Storage48
Krosflo® System Spare Parts49
Table 6. Krosflo® System Spare Parts49
Troubleshooting the System52
Table 7. Basic System Troubleshooting Steps52
Index53

REPLIGEN KrosFlo SYITF-2000

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