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REPLIGEN Spectrum KMPi User Manual

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53 400-12355-000 Rev. 03
KR2i / KMPi TFF Systems
Pump Head Setup and Operation
pump head should be tilted about 30° counterclockwise from the intended installed
orientation. Press pump head firmly against the drive and rotate clockwise until no more
rotation is possible (see Figure 4). The bayonet lock lever will automatically snap toward the
back of the pump, locking it to the mounting plate
3. Remove the pump head from the drive by holding the bayonet lock lever forward while
rotating the pump head as far as possible in the counterclockwise direction, then pull the
pump head away from the drive to detach it. The actuator lever should be in the far right
position when removing the pump head (see Figure 5)
KR2i Tubing
WARNING: Stop the pump drive before installing or removing tubing from the pump head.
1. To load tubing, open the pump head by moving the actuator lever counterclockwise (see
Figures 5 and 6). Insert a loop of tubing into one open tubing retainer, between the
occlusion bed and the rollers and into the other tubing retainer (see Figure 7). Position the
tubing so that it is firmly centered against the rollers. While holding the tubing ends, move
the actuator lever back to the far clockwise (right) position, as shown in Figure 5. The pump
head will automatically grip the tubing. Approximately 5 pounds of force must be applied to
the actuator lever to fully close the pump head and place the lever in its locked position (far
right position) or to fully open the pump head (far left position)
NOTE: It is unnecessary to have an end of the tubing free to load or unload tubing from the pump
head. A length of tubing may be loaded into the pump without disconnecting it from adjacent
devices.
1. Before unloading tubing from the pump head, first turn off the drive. Open the pump head
by moving the actuator lever counterclockwise (left), as described above. This will
automatically open the tubing retainers, as well as lift the occlusion bed away from the
tubing. Pull the tubing away from the pump head
NOTE: When pump is not being used, store with actuator lever half way between far left and far
right positions (see Figures 5 and 6).
Bayonet Lock
Lever-Pull Forward
to Release
Actuator
Lever-Far
Right Position
Occlusion Bed
Figure 5: Pump head in fully
closed position
Roller
Figure 6: Pump head in fully
open position
Actuator Lever-Far
Left Position

Table of Contents

Questions and Answers:

REPLIGEN Spectrum KMPi Specifications

General IconGeneral
ModelSpectrum KMPi
ManufacturerRepligen
ApplicationsTangential flow filtration
Operating PressureUp to 100 psi
Pressure RatingUp to 6 bar (87 psi)
Membrane AreaVariable, depending on module selection
MaterialStainless steel
Data LoggingIntegrated data logging capabilities
ConnectivityEthernet
DimensionsVaries depending on configuration
WeightVaries depending on configuration
CompatibilityCompatible with various TFF membranes

Summary

Safety Precautions

Explanation of Symbols

Explains warning symbols and their meanings, including Danger, Warning, and Caution.

Specifications

KR2i Specifications

Details technical specifications for the KR2i system, including output, input, construction, and environment.

KMPi Specifications

Details technical specifications for the KMPi system, covering output, input, construction, and environment.

System Configuration and Major Components

Setup and Operation

KF Comm Pump Control Interface

Details on using the KF Comm software for system control.

Hardware Setup

Configuring system hardware parameters and settings.

Automated Mode Control Strategy

Defining set-points and control mechanisms for automated processes.

Diafiltration Set Points

Options for controlling diafiltration endpoints.

Concentration Set Points

Options for controlling concentration endpoints.

Pressure Calibration Procedure

Steps for calibrating pressure sensors for accurate readings.

Alarms and Stops Configuration

Setting up safety alarms and operational stops for the system.

System Functionality

Detailed Pump Mode Operation

In-depth explanation of various pump operating modes.

Concentration Mode

Detailed operation of the Concentration Mode.

Concentration/Diafiltration Mode

Operation of the Concentration/Diafiltration Mode.

Constant Feed Concentration Mode

Operation of the Constant Feed Concentration (CFC) mode.

Ctrl Mode Operation

Operation of the Control Mode.

Pump Head Setup and Operation

KR2i Pump Head Operation

Procedures for installing and removing KR2i pump heads.

KMPi Pump Head Operation

Procedures for installing and operating KMPi pump heads.

Auxiliary Component Setup and Operation

Auxiliary Pumps Setup

Connecting and configuring auxiliary pumps.

Automatic Backpressure Valve

Setup and operation of automatic backpressure valves.

KONDUIT System Integration

Integrating the KONDUIT unit with the TFF system.

KF Comm Software

Installing and Updating KF Comm Software and Firmware

Guide to installing and updating system software and firmware.

Troubleshooting

Common Symptoms and Remedies

Identifies common issues and provides solutions.

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