Genevac HT-24 - Method Guide for Evaporation; Selecting Pre-programmed Evaporation Methods

Genevac HT-24
User Manual
38 10-1562 Issue 3-7 March 2014
Method guide
Pre-programmed runs
Genevac HT series II evaporators are pre-programmed with a number of evaporation
methods (runs) located at 51 to 60 of the SELECT RUN screen. The following table is a
guide to selecting the most suitable pre-programmed run. Runs 61 through to 98 are
associated, each run having a venting procedure linked to the end of the evaporation
process which helps to remove residual vapours from the chamber.
Note: Runs 99 and 100 are reserved for use by Genevac service engineers.
Each of the listed runs is designed to work for a group of solvents. Please bear in mind it is
usually possible to further optimise methods for specific solvents.
Run
number
Name
BP
range
Solvent
examples
Application
51
Volatiles - not
DCM
60 to
90°C
Ethyl acetate or
methanol
Single volatile solvents with no risk of
bumping
52
Very volatile &
DCM
40 to
90°C
DCM (methylene
chloride) or
chloroform
Volatile solvent mixtures, and DCM
(Methylene chloride), where risk of bumping
is high
53
Medium BP
solvents
90 to
155°C
DMF or Toluene
Medium BP solvent or mixture of medium
BP solvents
54
Med BP &
volatile
40 to
155°C
DMF & DCM
(methylene chloride)
Mixtures of medium and volatile solvents
with high risk of bumping
55
Pre-heat
chamber for
high BP
solvents
-
No solvents should
be present
Rapid pre-heat of chamber before a high BP
solvent run, swings and samples must be
removed before this method is used.
56
High BP 140+
140 to
190°C
DMF, DMAc, DMSO
High BP solvents
57
Very high BP
solvents
190°C +
NMP, DMI
Very high BP solvents
58
HPLC fractions
-
Water & acetonitrile
or methanol
HPLC fractions
59
Aqueous only
100°C
Water
Water only
60
Remove
stubborn
solvents
-
Any
Drying samples, which have not been fully
dried using another method. The condenser
must be empty before this method is used