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eRev. [Major Version]1.01.0 8/9/2023
KrosFlo® KR2i Real-Time Process Management (RPM™) System
1. Introduction
This user guide provides detailed instructions for the set up and operation of the KR2i RPM Tangential Flow Filtration (TFF) system
and auxiliary components. Included are descriptions of potential modes of operation and basic concepts of tangential flow filtration.
For questions and further information, please contact your Repligen representative.
The KrosFlo® KR2i RPM™ System is the first Tangential Flow Filtration (TFF) bench-scale system with integrated Real-time Process
Management (RPM). The System combines the KrosFlo® KR2i TFF System and the CTech™ FlowVPX® In-line spectrophotometer for
real-time concentration measurement and control. The KrosFlo® RPM™ software can execute complicated TFF processes through
user-specified set points for the system auxiliary pumps, scales, and backpressure valve.
The system is compatible with both hollow fiber (HF) membrane and TangenX flat sheet cassette TFF modules. The HF modules are
ideal for sample concentration, fractionation, and washing while avoiding membrane fouling and maximizing product recovery.
TangenX cassettes feature an inner screen that increases turbulence and gives high permeate flux, ideal for applications involving
viscous proteins, oligosaccharides, and viruses. Both module types are disposable to eliminate the potential for cross-contamination.
This user guide provides guidance for general use of the KrosFlo KR2i RPM System. For further optimization or troubleshooting
support, please contact our Customer Service team:
customerserviceUS@repligen.com
analytics-support@repligen.com
(908) 707-1009
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