Scale Required for Manual: Manual Mode will not start unless both Feed and Permeate Scales are
present.
Valve 2 (For KMPi Only): Select either if Valve 2 port is being used with Automatic backpressure
valve or with KONDUiT
Diafiltration and Concentration 1 and 2: Select the control mechanism for the automated mode
setpoints. The numbering scheme for concentration and diafiltration is sequential during the
automated mode.
For Example - Concentration 1 is the initial concentration as in the example below for CDDC mode
and the other modes are sequential:
6. Automated Mode Control Strategy
End point settings for concentration and diafiltration can be selected to be either by weight (CF
and DV) or, with the KONDUiT accessory, to be UV or Conductivity. Below are explanations and
example applications for different control strategies:
Diafiltration 1 Set Point:
1. DV (Diafiltration Volumes)
a. End-point control when permeate scale reaches target DV based on weight of feed
scale and holdup loop
b. Example Application: diafiltration of virus or protein
2. Cond 1
a. End-point control when conductivity reaches setpoint of Conductivity Sensor 1
b. Example Application: diafiltration of protein or oligo
3. UV
a. Semi-quantitative end-point control when UV reaches target AU
b. Example Application: diafiltration of latex particle with free IgG measurement on
permeate; offline confirmation needed for verification
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