Diafiltration 2 Set Point (Diaf 2 used in CDDC mode for second wash buffer):
1. DV (Diafiltration Volumes)
a. End-point control when permeate scale reaches target DV based on weight of feed
scale and holdup loop
b. Example Application: diafiltration of virus or protein
2. Cond 1
a. End-point control when conductivity reaches setpoint of Conductivity Sensor 1
b. Example Application: diafiltration of protein or oligo
3. UV
a. Semi-quantitative end-point control when UV reaches target AU
b. Example Application: diafiltration of latex particle with free IgG measurement on
permeate; offline confirmation needed for verification
Concentration 1 Set Point:
1. CF (Concentration Factor)
a. End-point control when retentate and permeate scale reaches target CF based on
weight of feed scale and holdup loop
b. Example Application: concentration of virus or protein
2. UV
a. Semi-quantitative end-point control when UV reaches target AU, Application
dependent, offline confirmation needed for verification
b. Example Application: concentration of oligo
3. UV2
1. Semi-quantitative end-point control when UV reaches target AU, Application
dependent, offline confirmation needed for verification
2. Example Application: concentration of oligo
Concentration 2 Set Point (Conc 2 used for final concentration in CDC):
1. CF (Concentration Factor)
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