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TSQ Quantiva
Thermo Scientific TSQ Quantiva User Manual
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Contents
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TSQ Endura and
TSQ Quantiva Hard
ware Manual
Thermo Scient
ific
9
11
Table of Contents
Default Chapter
7
Default Chapter
7
Table of Contents
7
Preface
13
Accessing Documentation
13
Special Notices, Symbols, and Cautions
14
Contacting Us
18
Chapter 1 Introduction
19
Introduction
19
Mass Spectrometer Models
20
Overview of an LC/MS Analysis
21
Figure 1. Functional Block Diagram of the TSQ Endura and TSQ Quantiva Systems
23
LC/MS Functional Block Diagram
23
Controls and Indicators
24
Leds
24
Figure 2. TSQ Endura and TSQ Quantiva Front Panel Leds
24
Power Entry Module
25
Figure 3. Power Entry Module
25
Communications Panel
26
Figure 4. Communication Connectors (Right Side of the MS)
27
Electronic Assemblies
24
Cooling Fans
29
Chapter 2 Scan Parameters
31
Scan Types
31
Full Scan Q1 and Q3 Scan Types
32
Selected Ion Monitoring Scan Type
33
Product Scan Type
33
Figure 5. Illustration of Product Scan Type
34
Precursor Scan Type
35
Figure 6. Illustration of the Precursor Scan Type
35
Neutral Loss Scan Type
36
Figure 7. Illustration of the Neutral Loss Scan Type
37
Figure 8. Examples of Compounds with a Common Neutral-Loss Fragment
37
Selected Reaction Monitoring Scan Type
38
Scan Mass-To-Charge Ratio Ranges
38
Data Types
38
Ion Polarity Modes
39
Chapter 3 Vacuum System
41
Schematic of the Internal Gas Supply Lines
42
Figure 9. Functional Block Diagram of the Vacuum System
42
Figure 10. Schematic of the Internal Gas Supplies
42
Inlet Gases Hardware
43
Figure 11. Gas Inlets and Vacuum (Foreline) Port (Left Side of the MS)
43
Argon Gas Valves
44
Nitrogen Gas Valves
44
Vent Valve
44
Vacuum Manifold
45
Vacuum Gauges
45
Vacuum Pumps
46
Figure 12. Placement of the Turbomolecular Pump Next to the Vacuum Manifold
46
Atmospheric Pressure Ionization Source
47
Figure 13. Ion Max NG and EASY-Max NG Ion Sources
47
API Source Interface
48
Figure 14. API Source Interface (TSQ Endura MS Cross Section)
48
Figure 15. Ion Transfer Tubes
49
Figure 16. RF and Exit Lenses for the Mass Spectrometers
50
Vacuum System
41
Vacuum System Functional Block Diagram
41
Chapter 4 Ion Transmission and Mass Analysis
51
Ion Optics
51
Figure 17. Schematic of the Mass Spectrometer Ion Transmission Path
51
Figure 18. MP00 RF Lens
52
Figure 19. Lens L0
52
MP00 Ion Optics
52
Figure 20. Multipole MP0 and Beam Blocker
53
Figure 21. TK1 (Left) and TK2 (Right) Lenses
53
MP0 Ion Optics
53
Mass Analyzers
54
Quadrupole Rod Assemblies
54
Figure 22. Quadrupole Q1 or Q3 (TSQ Endura MS)
54
Figure 23. Hyperquad Q1 or Q3 (TSQ Quantiva MS)
54
Applied RF and DC Fields
55
Figure 24. Quadrupole Q2 (Bottom) Separated from the Active Collision Cell Housing
55
Figure 25. Polarity of the RF and DC Voltages Applied to the Q1 and Q3 Mass Analyzers
55
Figure 26. Magnitude of the Asymmetric RF and DC Voltages Applied to the Q1 and
56
Mass Analysis
57
Collision Cell and CID Efficiency
57
Quadrupole Offset Voltage
58
Mass Analyzer Lenses
58
Dual-Mode, Discrete-Dynode Ion Detection System
59
Chapter 5 Syringe Pump and Divert/Inject Valve
61
Syringe Pump
61
Divert/Inject Valve
62
Figure 27. Syringe Pump Setup (Top View)
62
Configurations
63
Figure 28. Divert/Inject Valve Positions
63
Controlling the Divert/Inject Valve
64
Figure 29. Divert/Inject Valve Plumbed as a Loop Injector and as a Divert Valve
64
Figure 30. Divert/Inject Valve (Front View)
64
Chapter 6 System Shutdown, Startup, and Reset
65
Shutting down the System in an Emergency
65
Placing the Mass Spectrometer in Standby Mode
66
Turning on the Mass Spectrometer
66
Shutting down the Mass Spectrometer Completely
67
Starting the System after a Complete Shutdown
68
Starting the LC
68
Starting the Data System
68
Starting the Mass Spectrometer
68
Starting the Autosampler
69
Resetting the Mass Spectrometer
70
Resetting Calibration Parameters
70
Restarting the Data System
71
On/Off Status for MS Components under Varying Power Conditions
71
Chapter 7 Daily Operation
73
Before Operating the Mass Spectrometer
73
Checking the System Mode
74
Checking the Vacuum Pressure Levels
74
Checking the Gas Supplies
76
After Operating the Mass Spectrometer
76
Flushing the Inlet Components
76
Purging the Oil in the Forepump
77
Emptying the Solvent Waste Container
78
Placing the System in Standby Mode
78
Chapter 8 Maintenance
79
Maintenance Schedule
80
Guidelines
81
Tools and Supplies
81
Maintaining the API Source Housing
83
Maintaining the API Source Interface
84
Cleaning the Ion Sweep Cone, Spray Cone, and Ion Transfer Tube
84
Figure 31. Ion Sweep Cone Removed from the MS Mount Assembly
85
Figure 32. Ion Transfer Tube Removal Tool (TSQ Endura MS)
86
Figure 33. Ion Transfer Tube Removal Tool (TSQ Quantiva MS)
86
Figure 34. Spray Cone, O-Ring, Ion Transfer Tube, and Ion Sweep Cone (TSQ Endura MS)
87
Removing the API Source Interface
89
Cleaning the RF Lens, Exit Lens, MP00 RF Lens, and Lens L0
90
Figure 35. API Source Interface Removed from the Vacuum Manifold (TSQ Endura MS)
90
Figure 36. Removing the Multipole MP00 and Lens L0 Assembly
91
Figure 37. Removing the RF Lens and Exit Lens (TSQ Endura MS)
92
Figure 38. Removing the Lens L0 and Multipole MP00 from the MP00-L0 Mount Cage
92
Reinstalling the API Source Interface
94
Maintaining the Forepumps
94
Maintaining the Air Filter
94
Figure 39. Air Filter Location in the Mass Spectrometer with the Front Cover Removed
95
Chapter 9 Diagnostics and PCB and Assembly Replacement
97
Running the System Diagnostics
97
Replacing Fuses, Pcbs, and Power Supplies
98
Chapter 10 Replaceable Parts
99
Chemical Kit
99
Calibration Kit
100
MS Setup Kit
101
Performance Specification Kit
101
Single Mechanical Pump Kit
102
Dual Mechanical Pumps Kit
102
TSQ Source Installation Kit
103
API Source Interface
103
Miscellaneous Parts
103
Glossary
105
Index
111
4
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Thermo Scientific TSQ Quantiva Specifications
General
Brand
Thermo Scientific
Model
TSQ Quantiva
Category
Laboratory Equipment
Language
English
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