Thermo Scientific TSQ Endura and TSQ Quantiva Hardware Manual xi
Figure 1. Functional block diagram of the TSQ Endura and TSQ Quantiva systems . . . . . 5
Figure 2. TSQ Endura and TSQ Quantiva front panel LEDs . . . . . . . . . . . . . . . . . . . . . . . 6
Figure 3. Power entry module . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7
Figure 4. Communication connectors (right side of the MS) . . . . . . . . . . . . . . . . . . . . . . . 9
Figure 5. Illustration of product scan type . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16
Figure 6. Illustration of the precursor scan type . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
Figure 7. Illustration of the neutral loss scan type . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
Figure 8. Examples of compounds with a common neutral-loss fragment . . . . . . . . . . . . . 19
Figure 9. Functional block diagram of the vacuum system . . . . . . . . . . . . . . . . . . . . . . . . 24
Figure 10. Schematic of the internal gas supplies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24
Figure 11. Gas inlets and vacuum (foreline) port (left side of the MS) . . . . . . . . . . . . . . . . 25
Figure 12. Placement of the turbomolecular pump next to the vacuum manifold . . . . . . . . 28
Figure 13. Ion Max NG and EASY-Max NG ion sources . . . . . . . . . . . . . . . . . . . . . . . . . . 29
Figure 14. API source interface (TSQ Endura MS cross section) . . . . . . . . . . . . . . . . . . . . 30
Figure 15. Ion transfer tubes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31
Figure 16. RF and exit lenses for the mass spectrometers . . . . . . . . . . . . . . . . . . . . . . . . . . 32
Figure 17. Schematic of the mass spectrometer ion transmission path . . . . . . . . . . . . . . . . . 33
Figure 18. MP00 RF lens . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34
Figure 19. Lens L0 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .34
Figure 20. Multipole MP0 and beam blocker . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35
Figure 21. TK1 (left) and TK2 (right) lenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35
Figure 22. Quadrupole Q1 or Q3 (TSQ Endura MS) . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36
Figure 23. Hyperquad Q1 or Q3 (TSQ Quantiva MS) . . . . . . . . . . . . . . . . . . . . . . . . . . . 36
Figure 24. Quadrupole Q2 (bottom) separated from the active collision cell housing
(top) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37
Figure 25. Polarity of the RF and DC voltages applied to the Q1 and Q3 mass analyzers . . 37
Figure 26. Magnitude of the asymmetric RF and DC voltages applied to the Q1 and
Q3 rods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38
Figure 27. Syringe pump setup (top view) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44
Figure 28. Divert/inject valve positions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
Figure 29. Divert/inject valve plumbed as a loop injector and as a divert valve . . . . . . . . . . 46
Figure 30. Divert/inject valve (front view) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46
Figure 31. Ion sweep cone removed from the MS mount assembly . . . . . . . . . . . . . . . . . . 67
Figure 32. Ion transfer tube removal tool (TSQ Endura MS) . . . . . . . . . . . . . . . . . . . . . . . 68
Figure 33. Ion transfer tube removal tool (TSQ Quantiva MS) . . . . . . . . . . . . . . . . . . . . . 68
Figure 34. Spray cone, O-ring, ion transfer tube, and ion sweep cone (TSQ Endura MS) . . 69
Figure 35. API source interface removed from the vacuum manifold (TSQ Endura MS). . 72
Figures
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