Agilent InfinityLab LC Series Vialsamplers User Manual 367
13 Appendix
Solvent Information
Solvent Information
Observe the following recommendations on the use of solvents.
• Brown glass ware can avoid growth of algae.
• Avoid the use of the following steel-corrosive solvents:
• solutions of alkali halides and their respective acids (for example, lithium
iodide, potassium chloride, and so on),
• high concentrations of inorganic acids like sulfuric acid and nitric acid,
especially at higher temperatures (if your chromatography method allows,
replace by phosphoric acid or phosphate buffer which are less corrosive
against stainless steel),
• halogenated solvents or mixtures which form radicals and/or acids, for
example:
2CHCl
3
+ O
2
→ 2COCl
2
+ 2HCl
This reaction, in which stainless steel probably acts as a catalyst, occurs
quickly with dried chloroform if the drying process removes the stabilizing
alcohol,
• chromatographic grade ethers, which can contain peroxides (for example,
THF, dioxane, diisopropyl ether) should be filtered through dry aluminium
oxide which adsorbs the peroxides,
• solvents containing strong complexing agents (e.g. EDTA),
• mixtures of carbon tetrachloride with 2-propanol or THF.
• Avoid the use of dimethyl formamide (DMF). Polyvinylidene fluoride (PVDF),
which is used in leak sensors, is not resistant to DMF.
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