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Chronobiology
This page will calculate the chronobiology functions: M10, L5, RA, Intradaily
Variability (IV) and Interdaily Stability (IS).
The chronobiology functions were developed based on the research entitled
"Alterations in the circadian rest-activity rhythm in aging and Alzheimer's
disease." from Witting et. al., 1990.
The M10 is calculated by the average value of followed 10 hours of greatest
activity.
The O_M10 (onset M10) is the start date and time of the M10 period.
The L5 is calculated by the average value of followed 5 hours of lower
activity.
The O_L5 (onset L5) is the start date and time of the L5 period.
The RA (Relative Amplitude) is calculated by the following formula:
The IV (Intradaily Variability) function is calculated by the following formula:
The IS (Interdaily Stability) function is calculated by the following formula:
All calculations were developed based on the work:
Witting W, Kwa IH, Eikelenboom P, Mirmiran M, Swaab DF. Alterations in the
circadian rest-activity rhythm in aging and Alzheimer's disease. Biol
Psychiatry 1990;27:563-72.
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