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Chapter 1: ImageXpress Pico Automated Cell Imaging
System
The ImageXpress® Pico Automated Cell Imaging System is an all-in-one platform for
automatically acquiring and analyzing images from fluorescently labeled biological samples in
plates and slides. It enables you to increase the throughput of your image acquisition and
analysis, allowing you to gain insights in minutes. With the addition of a modular option, the
system provides environmental control for live cell imaging.
The core hardware component of the imaging system is a custom-designed, fully automated,
epi-illumination fluorescence microscope. The rapid autofocus and precision sample
movement features of the microscope allow large numbers of high-resolution images to be
acquired in the shortest possible time. All key optical and mechanical elements are motorized,
which allows complete control of the instrument configuration.
When used in combination with the CellReporterXpress® Image Acquisition and Analysis
Software, which features powerful image analysis capabilities and more than 25 available
predefined experimental protocols, the ImageXpress Pico system becomes an extremely
flexible device, ideally suited for user-defined, automated assays.
Key components of the instrument include the following:
Built-in, internal light source comprised of six high-powered LEDs enables very high
sensitivity fluorescent imaging. Additional LED-based light sources allow transmitted light
and overview imaging.
High-sensitivity, 5-megapixelCMOScamera.
Hardware-based autofocus system with precision motorized Z-stage focus.
High-transmission fluorescence imaging optics with world-class chromatic aberration
correction, resolution, and image flatness.
Secondary camera provides overview imaging for slides.
Precision motorized sample (X-Y) stage.
High-quality Leica objectives in a six-position turret.
Filter cubes in a six-position turret.
Motorized selection of stage position, filter cubes, and objectives.
Temperature control up to 40°C (104°F) for live cell imaging.
Optional environmental control system, which enables you to regulate humidity, CO
2
, and
O
2
inside the environmental control cassette for multi-day, live-cell, time-lapse imaging.
Operation and configuration control by the integrated CellReporterXpress software.
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