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XCell ATF Series User Manual

XCell ATF Series
87 pages
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XCell
TM
ATF System
With C410:V3 Controller
USER GUIDE
XCell
ATF4
XCel
l
ATF6
XCell
ATF10
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XCell ATF Series Specifications

General IconGeneral
BrandXCell
ModelATF Series
CategoryLaboratory Equipment
LanguageEnglish

Summary

Description of XCell™ ATF System and Process

XCell™ ATF System Pump Cycle

Explains the alternating flow generated by the diaphragm pump.

XCell™ ATF System Control Scope and Objectives

Outlines the functions and goals of the C410:V3 controller.

XCell™ ATF Pump Housing and Controller Pairings

Lists compatible pump housing and controller models and their features.

XCell™ System Interconnectivity Drawing

Illustrates how the controller, pump, and bioreactor connect.

Utility Requirements

Size and Weight

XCell™ ATF Pump Housing Assemblies

C410:V3 Controller Layout

General Layout

Describes the E-Box and P-Box components and their interconnections.

Filtration Assembly Components

Details the components included in the Filtration Assembly.

C410:V3 Controller Process and Control

Interface and Screens

Outlines the Operator Interface Terminal (OIT) features and primary/secondary screens.

Control Overview

Provides general rules for diaphragm motion and controller logic.

Start-up

Provides a startup guide for an XCell™ ATF System connected to a bioreactor.

Examples

Provides examples of process control settings for different scenarios.

Hollow Fiber Module and Diaphragm Replacement

Separating the Filtration Assembly from the Bioreactor

Details steps to disconnect the filtration assembly from the bioreactor.

HFM Removal

Provides steps for removing the Hollow Fiber Module from the assembly.

HFM Insertion

Guides on how to properly insert a new HFM.

Screen Module Replacement

Directs users to contact Repligen for screen module replacement.

Diaphragm Replacement

Explains diaphragm replacement procedures for different ATF systems.

Sterilization

Preparation of Filtration Assembly for Autoclaving

Lists pre-autoclaving checks and procedures for the assembly.

Autoclave Cycle

Outlines typical autoclave cycle parameters and procedures for sterilization.

Sterilization of Filtrate / Harvest Line

Covers sterilization of the filtrate/harvest line.

Connection to Bioreactor

Hard Connection

Details the procedure for making a hard connection to a bioreactor.

Maintenance

Diaphragm

Recommends diaphragm replacement for each new run.

Pump Air Inlet Filter

Explains when to replace the pump air inlet filter.

"O" Rings, Gaskets and Quick Connects

Advises on periodic replacement of O-rings and gaskets.

Controller Maintenance

Outlines bi-annual and four-year maintenance tasks for the controller.