Agilent InfinityLab LC Series 1260 Infinity II Isocratic- and Quaternary Pumps User Manual 25
Introduction
1
Overview of the Hydraulic Path
How Does Compressibility Compensation Work?
The compressibility of the solvents in use will affect retention-time stability
when the back pressure in the system changes (for example, ageing of
column). In order to minimize this effect, the pump provides a compressibility
compensation feature which optimizes the flow stability according to the
solvent type. The compressibility compensation is set to a default value and
can be changed through the user interface.
Without a compressibility compensation the following will happen during a
stroke of the first piston. The pressure in the piston chamber increases and
the volume in the chamber will be compressed depending on back pressure
and solvent type. The volume displaced into the system will be reduced by the
compressed volume.
With a compressibility value set the processor calculates a compensation
volume, that depends on the back pressure of the system and the selected
compressibility. This compensation volume will be added to the normal stroke
volume and compensates the previously described loss of volume during the
delivery stroke of the first piston.
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