10. To clean the components, see Cleaning the differential aperture (Page 44) and Cleaning
the ion guide assembly (Page 45).
3.10.2 Cleaning the differential aperture
Required tools and materials
• Chemical-resistant, powder-free gloves
• Suitable glass vessel in which to completely immerse the differential aperture when cleaning
• HPLC-grade deionized water
• Waters MS Cleaning Solution (186006846) or HPLC-grade (or better) 1:1 methanol/water
• Holding container for used cleaning solution
• Ultrasonic bath
• Source of oil-free, inert gas (for example, nitrogen) for drying
Warning: To avoid personal contamination with biologically hazardous or toxic compounds,
wear clean, chemical-resistant, powder-free gloves when performing this procedure.
To clean the differential aperture:
1. Place the differential aperture in the glass vessel.
2. Add Waters MS Cleaning Solution or 1:1 methanol/water to the vessel until the differential
aperture is immersed completely.
3. Place the vessel containing the differential aperture in the ultrasonic bath for 20 minutes.
4. Carefully pour the cleaning solution from the vessel holding the differential aperture into the
holding container, retaining the differential aperture in the vessel.
Tip: You can reuse Waters MS Cleaning Solution for one subsequent cleaning.
5. Flush with deionized water until all the MS cleaning solution is removed.
Important: Ensure that no MS Cleaning Solution remains on the component before
continuing this procedure.
6. Fill the vessel with isopropyl alcohol, ensuring that the differential aperture is immersed
completely.
7. Place the vessel containing the differential aperture in the ultrasonic bath for 20 minutes.
8. Carefully remove the differential aperture from its vessel and blow-dry the component
using inert, oil-free gas.
9. Discard the used isopropyl alcohol, using an appropriate waste container.
August 20, 2021, 715005003 Ver. 04 (Previously released as Revision C)
Page 44
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