Figure 3–12: Cleaning the ion guide
Ion guide
2. Add Waters MS Cleaning Solution or 1:1 methanol/water to the glass vessel until the ion
guide is immersed completely.
3. Place the vessel containing the ion guide in the ultrasonic bath for 20 minutes.
4. Carefully pour the cleaning solution from the vessel holding the ion guide into the holding
container, retaining the ion guide in the vessel.
Tip: You can reuse Waters MS Cleaning Solution for one subsequent cleaning.
5. Flush with deionized water until all the MS cleaning solution is removed.
Important: Ensure that no MS Cleaning Solution remains on the component before
continuing this procedure.
6. Fill the vessel with isopropyl alcohol, ensuring that the ion guide is immersed completely.
7. Place the vessel containing the ion guide in the ultrasonic bath for 20 minutes.
8. Carefully remove the ion guide from its vessel and blow-dry the component using inert, oil-
free gas.
9. Discard the used isopropyl alcohol using an appropriate waste container.
3.10.4 Fitting the ion guide assembly to the instrument
Required tools and materials
• Chemical-resistant, powder-free gloves
• 2.5-mm hex wrench
August 20, 2021, 715005003 Ver. 04 (Previously released as Revision C)
Page 46
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