Waters Xevo TQ-S cronos

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Figure 3–2: Probe adapter types

ESI probe adapter

APCI probe adapter

ESI identification label

APCI probe heater

ESI probe tip

APCI identification label

January 10, 2022, 715006200 Ver. 01 (previously released as Rev. A)

Page 49

Main Page

General Information2
Copyright Notice2
Trademarks2
Customer Comments3
Contacting Waters3
Additional Resources4
Intended Use of the Xevo TQ-S Cronos5
Calibrating5
Quality Control6
EMC Considerations6
FCC Radiation Emissions Notice6
ISM Classification: ISM Group 1 Class a6
EMC Emissions7
EMC Grounding Requirements7
Legal Manufacturer7
Safety Considerations7
Applicable Symbols7
Safety Hazard Symbol Notice9
Electrical Power Safety Notice9
Equipment Misuse Notice9
Considerations Specific to the Device10
Safe Disposal13
Safety Advisories14
Table of Contents15
Waters Xevo TQ-S Cronos Overview21
Automation and Fluidics22
ACQUITY UPLC-MS Xevo TQ-S Cronos Systems23
Compatible Systems - Xevo TQ-S Cronos23
ACQUITY System Core Components23
Waters ACQUITY Xevo TQ-S Cronos UPLC-MS System26
Software and Data System26
Ionization Techniques and Source Probes27
Electrospray Ionization27
Esci28
Apci28
Unispray Source28
Atmospheric Solids Analysis Probe (ASAP)28
Fluidics System29
Overview29
System Components30
System Operation30
Ion Optics30
MS Operating Modes31
MS/MS Operating Modes32
Product (Daughter) Ion Spectrum33
Precursor (Parent) Ion Spectrum33
MRM Mode34
PICS Mode34
RADAR Mode34
Constant Neutral Loss Mode35
Sample Inlet36
Leak Sensors36
Vacuum System36
Rear Panel36
Preparing the Mass Spectrometer for Operation38
Preparing to Start the Mass Spectrometer38
Starting the Mass Spectrometer Using Masslynx Software39
Starting the Mass Spectrometer Using Waters_Connect Software40
Verifying the Instrument's State of Readiness42
Monitoring the Mass Spectrometer Leds42
Power LED42
Operate LED42
Tuning and Calibration Information42
Running the Mass Spectrometer at Higher Flow Rates42
Preparing the Fluidics System43
Installing the Reservoir Bottles43
Installing the Low-Volume Vials44
Purging the Fluidics44
Rebooting the Mass Spectrometer45
Leaving the Mass Spectrometer Ready for Operation45
Emergency Shutdown of the Mass Spectrometer46
Changing the Mode of Operation47
ESI, Esci, and APCI Modes47
ESI Mode47
Esci Mode47
APCI Mode48
Configuring for Esi/Esci/Apci Modes48
Installing the Probe Adapter51
Installing the Probe Assembly54
Removing and Refitting the Probe Inlet Fitting60
Connecting the Probe Assembly to a UPC² System62
Removing the Probe Adapter64
Installing and Removing the Corona Pin65
Unispray Standard Source67
Installing the Unispray Source69
Removing the Unispray Source72
Maintenance Procedures74
Maintenance Schedule for Xevo TQ-S Cronos74
Spare Parts75
Safety and Handling76
Preparing the Instrument for Working on the Source76
Using Masslynx Software to Prepare the Instrument for Operations on or Inside Its Source77
Using Waters_Connect Software to Prepare the Instrument for Operations on or Inside Its Source77
Removing and Refitting the Source Enclosure78
Removing the Source Enclosure from the Instrument78
Fitting the Source Enclosure to the Instrument79
Operating the Source Isolation Valve80
Closing the Source Isolation Valve80
Opening the Source Isolation Valve81
Removing O-Rings and Seals82
O-Ring Removal Kit82
Cleaning the Instrument Case83
Emptying the Nitrogen Exhaust Trap Bottle83
Maintaining the Rotary Backing Pump's Oil85
Cleaning the Source Components88
Cleaning the Sampling Cone Assembly88
Removing the Sampling Cone Assembly from the Source88
Disassembling the Sampling Cone Assembly90
Cleaning the Sample Cone and Cone Gas Nozzle92
Assembling the Sampling Cone Assembly94
Fitting the Sampling Cone Assembly to the Source95
Cleaning the Ion Block Assembly96
Removing the Ion Block Assembly from the Source Assembly96
Disassembling the Source Ion Block Assembly98
Cleaning the Ion Block Components103
Assembling the Source Ion Block Assembly104
Fitting the Ion Block Assembly to the Source Assembly105
Cleaning the Ion Guide Assembly106
Removing the Pumping Block Assembly and Ion Guide Assembly from the Instrument106
Removing the Ion Guide Assembly and Differential Aperture from the Pumping Block Assembly108
Removing the Differential Aperture Support and the Differential Aperture from the Ion Guide Assembly109
Cleaning the Differential Aperture110
Cleaning the Ion Guide Assembly111
Fitting the Differential Aperture and the Differential Aperture Support Onto the Ion Guide Assembly113
Fitting the Ion Guide Assembly and Differential Aperture Onto the Pumping Block Assembly114
Fitting the Pumping Block Assembly and Ion Guide Assembly Onto the Instrument115
Replacing the Ion Block Source Heater116
Replacing the Probe Assembly120
Removing the Probe Assembly120
Replacing the ESI Probe Tip and Gasket122
Removing the ESI Probe Tip and Gasket122
Fitting the ESI Probe Tip and Gasket124
Cleaning the APCI Probe Tip125
Replacing the APCI Probe Heater126
Removing the APCI Probe Heater126
Fitting the New APCI Probe Heater127
Cleaning or Replacing the Corona Pin129
Replacing the Source Assembly Seals130
Removing the Probe Adjuster Assembly Probe and Source Enclosure Seals130
Fitting the New Source Enclosure and Probe Adjuster Assembly Probe Seals132
Replacing the Air Filter133
Replacing the Unispray Probe Assembly135
Removing the Unispray Probe Assembly135
Installing the Unispray Probe Assembly136
Maintaining the Unispray Impactor Pin138
Removing and Installing the Unispray Impactor Pin138
Cleaning or Replacing the Unispray Impactor Pin139
Replacing the Instrument's Fuses140
A Safety Advisories141
Warning Symbols141
Specific Warnings142
Notices144
Bottles Prohibited Symbol144
Required Protection144
Warnings that Apply to All Waters Instruments and Devices145
Warnings that Address the Replacement of Fuses149
Electrical Symbols150
Handling Symbols151
B External Connections153
External Wiring, Vacuum, and Gas Connections153
Connecting the Edwards Oil-Filled Backing Pump155
Making the Electrical Connections to the Rotary Backing Pump158
Connecting to the Nitrogen Gas Supply158
Connecting to the Collision Cell Gas Supply160
Connecting the Nitrogen Exhaust Line160
Connecting Liquid Waste Lines163
Connecting to the Workstation164
Connecting the Workstation to the Power Source165
Connecting Ethernet Cables (Systems with ACQUITY LC)165
I/O Signal Connectors166
Making I/O Signal Connections167
Connecting to the Power Supply170
C Materials of Construction and Compatible Solvents171
Preventing Contamination171
Items Exposed to Solvents171
Solvents Used to Prepare Mobile Phases172
D Plumbing the Fluidics System173
Preventing Contamination173
The Selector Valve173
Plumbing Schematic174
Tubing and Connection Specifications174

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