June 28, 2016, 715003956 Rev. C
Page 57
Mass spectrometer flammable solvents warning
This warning applies to mass spectrometers performing an analysis that requires the use of
flammable solvents.
Biohazard warning
The following warning applies to Waters instruments and devices that can process material
containing biohazards, which are substances that contain biological agents capable of producing
harmful effects in humans.
Biohazard and chemical hazard warning
These warnings apply to Waters instruments and devices that can process biohazards, corrosive
materials, or toxic materials.
Warning: To prevent ignition of flammable solvent vapors in the enclosed space of a mass
spectrometer’s ion source, ensure that nitrogen flows continuously through the source. The
nitrogen supply pressure must not fall below 600 kPa (6.0 bar, 87 psi) during an analysis
requiring the use of flammable solvents. Also a gas-fail device must be installed, to interrupt
the flow of LC solvent should the nitrogen supply fail.
Warning: To avoid infection with potentially infectious, human-sourced products,
inactivated microorganisms, and other biological materials, assume that all biological fluids
that you handle are infectious.
Specific precautions appear in the latest edition of the US National Institutes of Health (NIH)
publication, Biosafety in Microbiological and Biomedical Laboratories (BMBL).
Observe Good Laboratory Practice (GLP) at all times, particularly when working with
hazardous materials, and consult the biohazard safety representative for your organization
regarding the proper use and handling of infectious substances.
Warning: To avoid personal contamination with biohazards, toxic materials, or corrosive
materials, you must understand the hazards associated with their handling.
Guidelines prescribing the proper use and handling of such materials appear in the latest edition
of the National Research Council's publication, Prudent Practices in the Laboratory: Handling and
Management of Chemical Hazards.
Observe Good Laboratory Practice (GLP) at all times, particularly when working with hazardous
materials, and consult the safety representative for your organization regarding its protocols for
handling such materials.
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