Waters ACQUITY QDa - Solvents Used to Prepare Mobile Phases

June 28, 2016, 715003956 Rev. C
Page 76
C.4.2 Solvents used to prepare mobile phases
The following solvents and chemicals, which are used commonly to prepare mobile phase, and in
some cases act as sample diluents, are not expected to adversely affect the performance of the
materials shown in the table on page 75.
Note:
• The list of solvents and chemicals and their associated concentrations shown below
presents the levels which have been tested, assesed, or both, for chemical compatibility
with the materials of construction. It is not a recommendation for optimal electrospray
sensitivity. Mobile-phase component concentration affects electrospray efficiency and
sensitivity. Therefore, keep modifier and buffer concentrations to the lowest levels that
maintain chromatographic resolution.
• The solvents shown in the table below do not comprise a comprehensive listing. Some
solvents might be chemically compatible with the ACQUITY QDa Detector though they are
not referenced in the lists. Some solvents that are referenced in the lists but used at higher
concentrations than specified might also be compatible with the instrument. In such cases,
you must determine the compatibility of the solvents before using them.Where solvents are
used at higher concentrations than specified in the lists, it is important that you determine
whether their use is compatible with the instrument.
Waste bottle Polypropylene
Waste bottle push-in fittings NBR (nitrile butadiene rubber), SST (stainless
steel), PBT (polybutylene terephthalate), and
POM (polyoxymethylene)
Notice: For LC/MS operation, do not prepare mobile phases using tetrahydrofuran
(THF), and normal-phase solvents, like hexane. Such solvents adversely affect the
performance of the materials named in the list of items exposed to solvents, on page
page 75, and should not be used. In the event the solvents are used, at reduced
concentrations, as additives to mobile phases or as sample diluents, you must evaluate
the consequent compatibility issues.
Table C–6: Solvents used to prepare mobile phases (KAB)
Solution Concentration
Water 100%
Methanol 100%
Acetonitrile 100%
2-Propanol 100%
Formic acid
≤0.1%
Acetic acid
≤0.1%
Trifluoroacetic acid (TFA)
≤0.1%
Ammonium hydroxide
≤0.2%
Table C–5: Items exposed to solvent (KAB) (Continued)
Item Material