Waters ACQUITY QDa - Solvents Used Infrequently; Solvents Used Commonly as Diluents

June 28, 2016, 715003956 Rev. C
Page 74
C.3.3 Solvents used infrequently
The following reagents are used less frequently with electrospray ionization than those listed in the
previous table, because they decrease sensitivity. Nevertheless, they are often required for
suitable chromatographic resolution.
Note: At the concentrations specified below, the reagents are not expected to adversely affect the
performance of the materials shown in the list of items exposed to solvents on page 72. However,
you must keep concentrations to the lowest levels that maintain chromatographic resolution.
C.3.4 Solvents used commonly as diluents
The following solvents, often used as sample diluents, are not expected to adversely affect the
performance of the materials shown in the list of items exposed to solvents on page 72.
Ammonium hydroxide ≤1%
Ammonium formate ≤50 mM
Ammonium acetate ≤50 mM
Ammonium bicarbonate ≤50 mM
Tetrahydrofuran (THF) ≤15%
Table C–3: Solvents used infrequently
Solution Concentration
Diethylamine (DEA)
≤0.5%
Triethylamine (TEA)
≤0.5%
Hexafluoroisopropanol (HFIP)
≤5%
Hexyl Ammonium Acetate
≤50 mM
Table C–4: Solvents used commonly as diluents
Solution Concentration
Toluene
≤5%
Methyl tert-butyl ether (MTBE)
≤5%
Hexane
≤5%
Dichloromethane
≤2%
Dimethylformamide (DMF)
≤5%
Dimethyl sulfoxide (DMSO)
≤5%
Heptane
≤5%
Table C–2: Solvents used to prepare mobile phases (KAD) (Continued)
Solution Concentration