OsmoPRO® Multi-Sample Micro-Osmometer User’s Guide
78
C - Known limitations
• Additives such as anticoagulants from collection tubes may contribute to the measured
osmolality.
• Particulate matter can cause premature crystallization, i.e. sample pre-freeze. The
particulate matter may be eliminated in blood and urine by centrifugation. It may also be
eliminated in urine by filtration.
• Samples with air bubbles do not reliably freeze and may yield inaccurate results.
• Samples allowed to evaporate will yield higher osmolality values.
• Non-aqueous solutions will not yield accurate results. The OsmoPRO is intended to test
aqueous solutions only.
• Highly viscous solutions may not reliably freeze and may yield inaccurate results.
• High concentrations of ethanol, acetone, methanol, isopropanol, ethylene glycol, diethyl
ether, paraldehyde, trichloroethane, or propylene glycol may not reliably freeze and may
yield inaccurate results.
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