Idexx VetTest - Page 58

H–2
IDEXX VetTest* Chemistry Analyzer Operator’s Manual
In diseases such as viral hepatitis where the damage may be prolonged and
progressive, the enzyme release will also be prolonged. Here, removal of enzyme
from the circulation may not keep pace with enzyme release and the serum activity
will remain high for as long as damage continues. Monitoring enzyme activity can be
useful in determining whether or not a lesion is resolving. If blood samples are taken
sequentially and the enzyme activity is falling, the implication is that active cell damage
has ceased. If the activity remains elevated or increases, the implication is that damage
is continuing.
Enzyme Half-lives
5IFFO[ZNFIBMGMJGFJTUIFUJNFUBLFOGPSPGUIFTBNQMFFO[ZNFBDUJWJUZUPCF
removed from the circulation. This is often expressed as “t
½
w5IFIBMGMJGFJTEJGmDVMUUP
determine and may vary markedly with the enzyme and animal species. The following
UBCMFHJWFTBOBQQSPYJNBUJPOPGUIFIBMGMJWFTPGTPNFPGUIFEJBHOPTUJDFO[ZNFT
Enzyme Dog Cat
t
½
t
½
ALKP 120 h I
ALT (SGPT) I I
AMYL 12 h 12 h
AST (SGOT) 12 h I
CK I I
GGT 100 h *
LDH 18 h 30 h
LIPA 18 h 18 h
* no data available