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Chemistry Description and Guide
UPC Protocol
Principle reason for performing test:
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amyloidosis and as an early marker of chronic renal failure.
Includes:
Urine protein, urine creatinine, protein:creatinine ratio
Submission Requirements:
2 mL urine in a sterile container
Storage/Stability:
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Interferences:
Gross hematuria, pyuria. Complementary tests include complete urinalysis with culture
and sensitivity. Serum chemistries such as creatinine, BUN, albumin, globulin, CBC,
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Interpretation:
Proteinuria requires proof of persistence and localization to prerenal, renal or postrenal
origins. Prove persistence of proteinuria by repeating the UPC (urine protein:creatinine) ratio
at least three times, a minimum of two weeks apart.
Prerenal proteinuria is possible when a CBC and a biochemical profile detect t
hemolysis, hyperglobulinemia or evidence of muscle damage. Recommend
investigation and management for the underlying cause.
Postrenal proteinuria is caused by urogenital tract diseases, hematuria or pyuria. t
Repeat the test with a cystocentesis sample or evaluate urine sediment for
hemorrhage or inflammation. Consider a urine culture. Recommend investigation
and management for the underlying cause.
Renal proteinuria: evaluate in the face of azotemiat
Nonazotemic, persistent, renal proteinuria (dogs and cats):
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UPC 1.0–2.0=excessive proteinuria; recommend investigation for underlying
systemic diseases
UPC ≥2.0=excessive proteinuria; recommend investigation for underlying
systemic diseases and medical management
Azotemic, persistent, renal proteinuria (dogs):
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UPC ≥FYDFTTJWFQSPUFJOVSJBSFDPNNFOEJOWFTUJHBUJPOGPSVOEFSMZJOH
systemic diseases and medical management
Azotemic, persistent, renal proteinuria (cats):
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UPC ≥FYDFTTJWFQSPUFJOVSJBSFDPNNFOEJOWFTUJHBUJPOGPSVOEFSMZJOH
systemic diseases and medical management