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Chemistry Description and Guide
Urine Creatinine
Urine creatinine is determined so the concentration of electrolytes filtered or lost
through the glomeruli or renal tubules such as urinary protein or cortisol can be
quantitated, compared, and expressed as ratios with diagnostic significance.
Principal reason for performing the test:
To be performed with urine protein in order to determine the urine protein to creatinine
ratio (UPC).
Most common abnormality indicated by the test:
Proteinuria indicating early renal failure, protein losing nephropathy.
Sample type and precautions:
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urinary sediment should be demonstrated and urinary tract infection (UTI) via culture
and sensitivity should be ruled out before performing as UTI may mildly to moderately
raise the UPC.
Complementary tests:
Complete urinalysis with culture and sensitivity. Serum chemistries such as creatinine,
BUN, albumin, and globulin.
CBC
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Storage information:
Handle and store urine samples in closed containers to avoid evaporation and
contamination. Samples may be stored at room temperature for up to three days
(refrigeration preferred). Frozen samples can be stored indefinitely.
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