Troubleshooting 3-3
3. Evaluate parameters in this sequence to rule out simple problem causes:
a. System pressure
b. Baseline
c. Peak retention time
d. Peak resolution
e. Qualitative and quantitative chromatography results
Isolate the parameter whose behavior varies from its usual
performance during normal system operation.
4. Run the performance test for a specific module to quickly determine
whether a problem exists.
5. Use the troubleshooting flowcharts in “Troubleshooting flowcharts” on
page 3-5 to deduce a symptom’s possible cause.
6. See the table below to determine corrective actions.
General PrepLC troubleshooting
Symptom Possible cause Corrective action
Grinding or
shuddering noise
from pump - high
pressure shutdown
not exceeded
Blockage in system
before transducer
Clean pump head outlet
tubing, outlet check
valve and tubing to
transducer.
Mechanical problem Call Waters Technical
Service.
Pump shutting down,
high pressure limit
exceeded
High flow rate during
injection valve actuation
caused pressure spike
Decrease flow rate
during injection.
Blockage in system after
transducer
Remove components
between pump and end
of system to determine
source of blockage.
Eliminate blockage.
Column plugged Clean or replace column.
Pump shutting down,
low pressure limit
exceeded
Leaks, empty reservoirs,
or bubbles in the pump
head
Eliminate leaks, fill
reservoirs, prime pump.
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