P/N 53063-30, Manual revision: B
A-2
Providing Reference Information
COMPLICATIONS OF AND CONTRAINDICATIONS TO PERIOPERATIVE BLOOD
RECOVERY
Table A-1, Complications of and contraindications to perioperative blood recovery*
Substance Effects Recommended Action
Pharmacologic Agents
A. Clotting Agents
1. Microfibrillar Products
Examples:
Avitene
®
, Helitene
®
, Oxycel
®
,
Gelfoam
®
Powder, Instat
®
MCH
May cause platelet aggrega-
tion and clot formation.
Reported to pass through a
microaggregate filter into the
blood stream causing emboli.
Avoid aspiration when prod-
uct is being used. Resumption
is an option after copious irri-
gation with 0.9% sodium
chloride solution to an alter-
nate suction source.
2. Sponge/Fabric Materials
Examples:
Surgicel
™
, Surgicel
™
Nu-Knit
®
,
Gelfoam
®
Sponge, Helistat
®
,
Instat
™
, Hemopad
®
, Super
Stat
®
, HemoFoam
®
Activates clotting sequence by
acting as a contact agent.
May clot off system.
Avoid aspiration in area
where product is being used.
Resumption is an option after
copious irrigation with 0.9%
sodium chloride solution to
an alternate suction source.
3. Topical Liquids
Examples:
Thrombin-JMI
™
, Throm-
bostat
®
, Thrombogen
®
Creates a fibrin clot by direct
action on fibrinogen.
May clot off system.
Avoid aspiration in area
where product is being used.
Resumption is an option after
copious irrigation with 0.9%
sodium chloride solution to
an alternate suction source.
B. Irrigating Solutions
1. Alcohol Causes red cell lysis. Avoid aspiration in area
where product is being used.
Resumption is an option after
copious irrigation with 0.9%
sodium chloride solution to
an alternate suction source.
2. Antibiotics
Examples:
Bacitracin, Neomycin, Poly-
myxin
Can result in renal and neuro
toxicity if blood is not
washed.
Increase amount of wash vol-
ume by 500 ml.
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