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Osmo1® Single-Sample Micro-Osmometer User Guide
Appendix C
Known limitations
• Additives such as anticoagulants from collection tubes may contribute to the measured osmolality.
• Particulate matter can cause premature crystallization, such as sample pre-freeze. The particulate matter may be
eliminated in blood and urine by centrifugation. It may also be eliminated in urine by filtration.
• Samples with air bubbles do not freeze reliably and may yield inaccurate results.
• Samples allowed to evaporate will yield higher osmolality values.
• Non-aqueous solutions will not yield accurate results. The Osmo1 is intended to test aqueous solutions only.
• Highly viscous solutions may not freeze reliably and may yield inaccurate results.
• High concentrations of ethanol, acetone, methanol, isopropanol, ethylene glycol, diethyl ether, paraldehyde,
trichloroethane, or propylene glycol may not freeze reliably and may yield inaccurate results.
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