Appendix
Operator´s Manual PiCCO
2
Page
Version 3.1 E-13
CO = [(Tb – Ti) x Vi x K] / [³'Tb x dt]
where CO = Cardiac Output (l/min)
Tb = Blood temperature before the injection of cold bolus (°C)
Ti = Temperature of the injection solution (injectate) (°C)
Vi = Injection volume (ml)
³'Tb x dt = Area under the thermodilution curve
K = Correction constants, made up of specific weights and specific heat
of blood and injectate
CI= CO / BSA
where CI = Cardiac Index (l/min/m
2
)
CO = Cardiac Output (l/min)
BSA = Body Surface Area (m
2
)
5.3 Preload Volume
GEDV = [CO x 1000] x [(MTt
TDa
– DSt
TDa
) / 60]
GEDV = ITTV - PTV
where GEDV = Global End-Diastolic Volume (ml)
ITTV = Intrathoracic Thermal Volume (ml)
where: ITTV = (CO x 1000) x MTt
TDa
PTV = Pulmonary Thermal Volume (ml)
where: PTV = (CO x 1000) x DSt
TDa
and
CO = Cardiac Output (l/min)
MTt
TDa
= Mean transit time of the cold indicator from the site of injection to
the site of detection
DSt
TDa
= Exponential downslope time of the arterial thermodilution curve
GEDI = GEDV / PBSA
where GEDV = Global End-Diastolic Volume (ml)
GEDI = Global End-Diastolic Volume Index (ml/m
2
)
PBSA = Predicted Body Surface Area (m²)
ITBV = 1.25 x GEDV
where ITBV = Intrathoracic Blood Volume (ml)
GEDV = Global End-Diastolic Volume (ml)