Table of Contents xi
Safety considerations .......................................................................................... iv
Instrument-specific safety considerations......................................................... iv
Flammable solvents hazard ................................................................................ v
High temperature hazard.................................................................................... v
High voltage hazard............................................................................................ vi
Safety advisories................................................................................................. vi
Operating this device ......................................................................................... vii
Symbols ............................................................................................................. vii
Intended use...................................................................................................... vii
Calibration ....................................................................................................... viii
Quality control................................................................................................. viii
IVD authorized representative information ................................................. ix
IVD authorized representative .......................................................................... ix
1 Waters TQ Detector Overview ............................................................ 1-1
Overview ............................................................................................................. 1-2
Waters TQ Detector......................................................................................... 1-2
ACQUITY TQD UPLC/MS system ................................................................. 1-4
MassLynx mass spectrometry software and data system ............................. 1-5
ACQUITY UPLC Console................................................................................ 1-6
Ionization techniques and source probes ................................................... 1-7
Electrospray ionization (ESI).......................................................................... 1-7
Combined electrospray ionization and atmospheric pressure chemical ionization
(ESCi) ......................................................................................................... 1-7
Atmospheric pressure chemical ionization..................................................... 1-8
Atmospheric pressure photoionization........................................................... 1-8
Table of Contents