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Waters TQ Detector - Ionization Techniques and Source Probes; Electrospray Ionization (ESI) Process; Combined ESI and APCI (ESCi) Mode

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Ion optics 1-9
Ion optics
The TQ Detector’s ion optics operate as follows:
Samples from the LC or Intellistart fluidics system are introduced at
atmospheric pressure into the ionization source.
The ions pass through the sample cone into the vacuum system.
The ions pass through the transfer optics to the first quadrupole where
they are filtered according to their mass-to-charge ratio (m/z).
The mass-separated ions pass into the T-Wave™ collision cell where
they either undergo collision-induced dissociation (CID) or pass to the
second quadrupole. Any fragment ions are then mass-analyzed by the
second quadrupole.
The transmitted ions are detected by the photomultiplier detection
system.
The signal is amplified, digitized, and sent to the MassLynx mass
spectrometry software.
Ion optics overview:
Sample cone
Isolation valve
T-Wave collision
cell
Z-Spray ion source Quadrupole 1
(MS1)
Quadrupole 2
(MS2)
Detector
Conversion dynode
Sample inlet Transfer optics

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