38 Purification Solution - Developer's Guide
4
Setting Up and Running a Purification Task
System Suitability Tests
System Suitability Tests
The system suitability tests are specific tasks of the preparative-only
workflow. They are used to purge the autosampler, flush the instrument and
submit a run of at least one known standard sample in order to verify that the
compounds in the sample are still eluting within the expected retention time
range and that their ion masses can still be detected. As such, the system
suitability tasks verify that the preparative instrument is (still) ready to run.
We recommend that you submit such task every morning before starting
purification. A system suitability task run should be repeated if you feel that
the instrument is not operating as it should. If a system suitability test fails,
then no regular tasks can be submitted until you fix the instrument and a
repeated system suitability run confirms the system readiness. As a method
developer, you can also classify a failed system suitability test run as accepted
to release the instrument for further task runs if you judge that the instrument
is capable of performing the required purification tasks.
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