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CoaguChek INRange User’s Manual
Introduction
16
Test principle The CoaguChek XS PT Test PST test strip con-
tains a lyophilized reagent (reagent in dried
form). The reactive components of this reagent
consist of thromboplastin and a peptide sub-
strate. When a sample is applied, thromboplastin
activates coagulation, which leads to the forma-
tion of thrombin. At the same time, the meter
starts to measure the time. The enzyme thrombin
cleaves the peptide substrate, generating an
electrochemical signal. Depending on the time
elapsed when it first appears, this signal is then
converted by means of an algorithm into cus-
tomary coagulation units (INR, %Quick, seconds)
and the result is displayed.
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