BeneVision N Series Patient Monitor Operator’s Manual 22 - 1
22 Monitoring Continuous Cardiac Output (from PiCCO 
Module)
22.1 CCO Introduction
The PiCCO method combines transpulmonary thermodilution and pulse contour analysis on the blood pressure 
waveform. A cold bolus (e.g. normal saline 0.9%) with a known volume and temperature is injected into the right 
atrium through a central venous catheter. The cold bolus mixes with the blood in the heart and the change in 
blood temperature is measured with a thermistor at the distal end of the arterial thermodilution catheter placed 
in one of the bigger systemic arteries, for example, the femoral artery. The monitor uses the transpulmonary 
thermodilution method to measure C.O., Global End Diastolic Volume (GEDV) and Extra Vascular Lung Water 
(EVLW). With the C.O. value measured with the transpulmonary thermodilution method and the result of the 
pulse contour analysis, a patient-specific calibration factor is calculated. The monitor uses this value to compute 
CCO and the other continuous hemodynamic parameters. 
PiCCO monitoring is intended for adult and pediatric patients.
22.2 CCO Safety Information
• PiCCO monitoring is not intended for neonatal patients.
• Use only pressure transducers specified in this manual. Never reuse disposable pressure 
transducers.
• Make sure that the applied parts never contact other conductive parts.
• To reduce the hazard of burns during high-frequency surgical procedure, ensure that the monitor’s 
cables and transducers never come into contact with the high-frequency surgical units.
• When using accessories, their operating temperature should be taken into consideration. For 
details, see instructions for use of accessories.
(1) CCO menu hard key (2) Zero IBP hard key
(3) IBP cable connector (4) PiCCO cable connector