repligen.com XC-LAB-UG-V4
5. XCell™ Lab Controller quick set-up for experienced users
If you are an experienced XCell ATF® user and already familiar with the Set-up Guide and Health and
Safety guidelines, then this section will help you get set-up quickly. If you need further guidance,
please review the full User Guide, including the Appendices, or reach out to a local FAS.
5.1 Connections
Connect all components as described below:
a. Orient the controller on the bench as you see appropriate for your bioreactor setup. A
maximum of two controllers can be stacked vertically.
b. Place the tablet in a convenient location, either on the controller or attached to a shelf.
c. Connect the air utility line to the SAPA, through the manifold and then to up to four
controllers. Use the supplied adaptors if needed.
d. Connect your lab vacuum supply or Repligen supplied vacuum pump to the vacuum manifold.
Use the supplied adaptors if needed.
e. Prepare the XCell ATF® Device(s) according to the appropriate Device Set-up Guide
.
f. Connect the XCell ATF® Device(s) to the bioreactor using the A2B tubing kit supplied by
Repligen.
g. Use the correctly sized/labelled A2C tubing for the XCell ATF® Device you plan to use.
h. Make sure the flow sensor is correctly oriented and stably positioned on the A2B tubing in a
location where air bubbles are not likely to collect within the tubing.
i. Connect the permeate pressure sensor (P3), if used.
j. To supply power to the controller, connect the 24 V adaptor to the wall power source.
k. Turn on the controller and tablet. By default, no logon credentials are required for the tablet.
The XCell™ Lab Software opens with the Supervisor account and displays the Overview screen
5.2 Software set-up
Please note the following:
• The newly designed software interface allows you to make real-time changes to the set points.
• During operation, certain buttons are pre-programmed to be greyed out and remain non-
functional to prevent unnecessary and undesired changes (for example, change of XCell ATF®
Device size is not allowed while the device is running).
• Certain options and buttons will not be visible if you are logged in as a User (limited access)
With auto login enabled, the default user level Supervisor allows complete access.
• Default settings typically are suitable for most processes; no further adjustments should be
required.
To get started:
a. On the main menu (top), click the Settings button, which displays the Settings sub-menu.
b. The first (and default) button, ATF configuration, allows selection of ATF size and filter type.
c. Click the second button, Bioreactor configuration, to change the default settings of one ATF
attached to a bioreactor.
d. Other buttons allow you to change date and time formats, pump settings, flow rates etc.
5.3 XCell ATF® Device start-up
a. Click the ATF button on the main menu to open the ATF Main Screen.
b. Click the ATF Flow box or the ATF graphic, both of which open a pop-up window.
c. Click Start. The priming sequence begins and the run starts.
Note: You can change the set points at any time before starting a run and during a run.
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