repligen.com XC-LAB-UG-V4
1. Introduction
The XCell ATF® Technology provides a complete solution for the retention of cells, removal of media
and, ultimately, the intensification of upstream cell culture processes. It is the most widely used and
proven cell retention solution in the world, having been specified in dozens of commercial
processes. Thousands of XCell ATF® systems are currently utilized in process development and
clinical manufacturing processes. As the gold standard for upstream process intensification, XCell
ATF® often delivers at least 10 times higher cell concentrations or product throughput than typical
batch and fed-batch processes.
The XCell ATF® System includes several components: a controller (with air and vacuum accessories),
software, sensors and XCell ATF® Device.
This User Guide serves as a reference document for your XCell™ Lab Controller and software;
updates are made on a regular basis. For the latest version of this document, please visit
the
Repligen website. Installation by a trained Repligen Field Service Engineer (FSE) is highly
recommended.
2. Welcome
Thank you for choosing the XCell™
Lab Controller for your laboratory and cell culture intensification
needs. This next generation system provides proven upstream intensification performance on an
industrial automation platform. The XCell™ Lab Controller combines performance intensification and
ease of use into a single solution. Key components include an easy-to-use software, flow sensors,
and air and vacuum accessories (Figure 1
).
The XCell™ Lab Controller is designed to meet the
challenges of the next wave of high-density intensification processes, which are expected to exceed
250 x 106 cells/mL.
F
igure 1. XCell™ Lab Controller and accessories
1. XCell™ Lab Controller
2. XCell™ Lab Software and HMI
3. Flow sensor
4. Supply air protection assembly
5. Vacuum manifold
6. Vacuum pump
Existing XCell ATF® users may jump to Section 5
f
or an abbreviated setup description.
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