REPLIGEN XCell Lab XC-LAB-S

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KrosFlo® TFDF™ Lab System

User Guide

XCell™ Lab Controller

User Guide

XC-LAB-UG-V4

TCP/IP Transmission control protocol / Internet protocol

UF Ultrafiltration

VCD Viable cell density

VDC Volt direct current

VT Volumetric throughput

VVD Vessel volume exchange per day

Main Page

Table of Contents3
Figure 1. Xcell™ Lab Controller and Accessories9
Table 1. Explanation of User Attention Phrases10
Table 2. Safety Precautions Examples10
Table 3. Safety Warnings11
Figure 2. ATF Pressure and Exhaust Strokes14
Figure 3. Backflush Example14
Figure 4. Configuration - Bioreactor, Controller, and Utilities15
Table 4. Xcell™ Lab Controller Model Comparison16
Figure 5. Face a of Controller17
Figure 6. Face B of Controller17
A2B and A2C Tubing Sets18
Table 5. Controller Ports18
Table 6. A2B Tubing ID/OD19
Table 7. SAPA Components19
Figure 7. SAPA Components Example19
Windows Environment20
Repligen Xcell™ Lab Software20
Modbus/Ethernet Remote Monitoring20
Figure 8. Touchscreen Splash Display Example21
Table 8. Preset Usernames and Passwords22
Figure 9. Login Screen Example22
Figure 10. Overview/Scada Screen Example22
Menu Bar24
Figure 11. Menu Bar Example24
Figure 12. User Information24
Figure 13. ATF Main Screen Example Two Xcell ATF® Devices Attached to same Vessel25
Figure 14. Example - 2 Synchronized Xcell ATF® Devices Attached to the same Bioreactor26
Figure 15. Example - 2 Xcell ATF® Devices Attached to Two Bioreactors26
Figure 16. Example - Dual Controller and Single Xcell ATF® Device27
Figure 17. ATF Flow Pop-Up Example27
Changing ATF Flow Set Points28
Starting, Pausing and Stopping an Xcell ATF® Device28
Pump Status Box28
Table 9. Starting, Pausing and Stopping an Xcell ATF® Device Instructions28
Figure 18. Xcell ATF® Device Status - Running, Paused or Stopped28
Dual Mode29
Table 10. Pump Status Messages Examples29
Table 11. ATF Modes - Independent and Dual30
Figure 19. ATF DUAL Pop-Up Example30
Table 12. Starting, Pausing and Stopping Xcell ATF® Device(S) in Dual Mode31
ATF Displacement Volume Pop-Up Window32
ATF Pressure Pop-Up Window32
Figure 20. ATF Displacement Volume Pop-Up Example32
Figure 21. ATF Pressure Pop-Up Screen Example32
Settings Sub-Menu33
Xcell ATF® Device Configuration33
Figure 22. Settings Sub-Menu Example33
Figure 23. Xcell ATF® Device Configuration Example33
Bioreactor Configuration34
Default Configuration/Atf Pump Settings34
Figure 24. Bioreactor Configuration Example34
Figure 25. ATF Pump Settings Example34
General Configuration35
Figure 26. General Configuration Example35
Service /Performance Screen36
Logon Required - Security On/Off36
Table 13. ATF Service Parameters36
Figure 27. Service/Performance Example36
Algorithm Pop-Ups37
Figure 28. ATF-A Algorithm Pop-Up Example37
Figure 29. ATF-A and ATF-B Algorithm Pop-Ups37
Xcell™ Lab Trend Screen38
Figure 30. Xcell™ Lab Trend Screen Example38
Figure 31. Alarm Condition Example39
Figure 32. Alarm Status39
Alarm Configuration40
ATF Flow Alarm Configuration40
Table 14. Alarm Status40
Figure 33. Alarm Configuration Example40
Displacement Volume Alarm Configuration41
System Alarm Configuration41
Figure 34. Displacement Volume Alarm Example41
Figure 35. System Alarms Example41
Permeate (P3) Pressure Alarm Configuration42
Figure 36. P3 Permeate Pressure Alarm Example42
Historian Client Software43
Trend43
Figure 37. Accessing Trend and Query Example43
Figure 38. Trend Screen Example43
Query Tool44
Exporting Data to Excel44
Figure 39. Query Example44
Figure 40. Columns Pane - Subset of the Query Window45
Figure 41. Query Set-Up45
Figure 42. Help Feature46
Figure 43. Workflow for a Typical ATF Start-Up Process47
Table 15. Recommended ATF Rate to Filtration Rate Ratios48
Table 16. Xcell™ Lab System Price and Parts List - for Sales51
Figure 44. Control Panel Network and Sharing Center56
Figure 45. Control Panel's Network Adapter Properties56
Figure 46. Windows 10 Network Adapter Tcp/Ipv4 Properties57
Table 17. Windows Usernames and Passwords60
Table 18. Xcell™ Lab Users and Roles60
Changing Usernames and Passwords61
Figure 47. Default Values for ATF Pump Configuration66
Figure 48. Default Values for ATF Flow Alarms66
Figure 49. Default Values for Displacement Volume Alarms67
Figure 50. Default Values for System Alarms67
Figure 51. Default Values for P3 Permeate Pressure Alarms68

REPLIGEN XCell Lab XC-LAB-S - Page 8

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