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Waters ACQUITY UPLC M-Class User Manual
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ACQUITY UPLC M-Class
System Guide
715003588
Revision C
Copyright © W
aters Corporation 2019
All rights reserved
2
Table of Contents
General Information
2
Trademarks
2
Customer Comments
3
Safety Considerations
3
Considerations Specific to the Modules that Comprise the ACQUITY UPLC M-Class System
4
FCC Radiation Emissions Notice
4
Canada Spectrum Management Emissions Notice
4
Electrical Power Safety Notice
4
Safety Hazard Symbol Notice
4
Equipment Misuse Notice
5
Safety Advisories
5
Operating the System
5
Applicable Symbols
5
Audience and Purpose
6
Intended Use of the ACQUITY UPLC M-Class System
6
Calibrating
6
Quality Control
7
ISM Classification: ISM Group 1 Class B
7
Table of Contents
8
1 ACQUITY UPLC M-Class System
12
Configurations of System Modules
12
Examples of Typical ACQUITY M-Class System Configurations
13
System Components
15
System Features
15
Auxiliary Solvent Manager
16
Μbinary Solvent Manager
16
Μsample Manager - Fixed Loop
17
Sample Organizer
17
Trap Valve Manager
17
Detection
17
Column Technology
18
Software
19
Options
19
Additional Information
20
2 Performance Optimization
22
Best Practices to Improve Performance
22
Autozeroing the Flow Transducers
22
Flow Ramping
22
Flow Rate on the B Flow Controller
23
Initial Gradient Hold
23
Trapping Flow Rate and Trapping Composition
23
Re-Equilibration of Column at the End of Analysis
24
System Equilibration after Auto Zero
24
Re-Equilibration between Methods
24
Temperature Sensitivity
24
General Guidelines for a Microscale System
25
Required Solvents
25
Dispersion
26
Carryover
26
Contamination
27
Contamination When Operating with Neutral or Basic Mobile Phases
28
Preventing Leaks
29
Installing Tubing and Fittings
29
Sample Preparation
47
3 Preparation and Operation
48
Preparing the System
48
Powering-On the System Hardware
48
Configuring the System Software
49
Monitoring Leds
49
Power LED
49
Status Leds
49
Starting the Instrument Console
51
Instrument Control Panels
52
Solvent Manager Control Panels
52
Μsm-FL Control Panel
54
TVM Control Panel
56
4 Maintaining the System
57
Contacting Waters Technical Service
57
Locating System Serial Numbers
57
Maintenance Procedure and Frequency
58
Troubleshooting
63
General Principles
63
Troubleshooting M-Class System Devices
64
Configuring Maintenance Warnings
74
Spare Parts
75
A Safety Advisories
76
Warning Symbols
76
Notices
77
Bottles Prohibited Symbol
77
Required Protection
78
Burst Warning
78
Biohazard Warning
78
Warnings that Apply to All Waters Instruments and Devices
79
Warnings that Address the Replacement of Fuses
83
Electrical Symbols
84
Handling Symbols
85
B Specifications
87
Features and Performance Specifications
87
Instrument Control
91
Environmental Specifications
91
Power Requirements
91
Physical Specifications
92
C External Connections
94
System Waste Routing
94
External Wiring Connections
95
Ethernet Connections
96
Signal Connections
96
Connecting Signal Cables
96
Connecting to the Electricity Source
98
Connecting to a Wall Electricity Source
98
Connecting to a Cart's Electricity Source
99
D Solvent Considerations
102
Solvent Guidelines
102
Clean Solvents
102
Solvent Quality
102
Solvent Preparation
102
Pure Water Is Required
103
Solvent Recommendations
103
Recommended Solvents
103
Solvents to Avoid
104
Recommended Cleaning Agents
104
Operation with Neutral or Basic Mobile Phases
104
System Recommendations
113
Solvent Manager Recommendations
113
Μsm-FL Recommendations
114
Properties of Common Solvents
114
Solvent Miscibility Effects
115
Using Miscibility Numbers (M-Numbers)
116
Solvent Viscosity
117
4
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Waters ACQUITY UPLC M-Class Specifications
General
Brand
Waters
Model
ACQUITY UPLC M-Class
Category
Laboratory Equipment
Language
English
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